C. Bustamante

Coxsackievirus infection induces direct pancreatic β-cell killing but poor anti-viral CD8+ T-cell responses

This study shows that Coxsackievirus B directly kills pancreatic β-cells and elicits weak CD8+ T-cell responses, suggesting vaccination could prevent type 1 diabetes.

Hyperbolic Geometry-Based Deep Learning Methods to Produce Population Trees from Genotype Data

This paper introduces deep learning models using hyperbolic geometry to generate population trees from genotype data, showing improved performance and generalizability compared to traditional methods.

Rigid DNA nanotube tethers suppress high frequency noise in dual-trap optical tweezers systems

This study evaluates how rigid DNA nanotube tethers affect noise in dual-trap optical tweezers systems, finding they suppress high-frequency noise but not low-frequency noise.

Molecular Organization of the Early Stages of Nucleosome Phase Separation Visualized by Cryo-Electron Tomography

This study uses cryo-electron tomography and deep learning to visualize the molecular organization of nucleosome phase separation stages, revealing a two-step process and the role of histone H1 in condensate transformation.

Single-molecule diffusometry reveals no catalysis-induced diffusion enhancement of alkaline phosphatase as proposed by FCS experiments

The paper uses single-molecule techniques to show catalysis does not enhance diffusion of alkaline phosphatase, contradicting previous FCS results attributed to substrate-induced dye blinking.

Atomic force microscopy visualizes mobility of photosynthetic proteins in grana thylakoid membranes

This study uses high-speed atomic force microscopy to visualize and characterize the mobility of photosynthetic protein complexes in grana thylakoid membranes, revealing heterogeneous mobility patterns and rotational diffusion.

A DNA translocase operates by cycling between planarand lock-washer structures

The paper studies a DNA translocase that adapts its translocation mechanism to different substrates by altering its structural conformation.

High-resolution and high-accuracy topographic and transcriptional maps of the nucleosome barrier

The paper maps nucleosome barriers' topography and Pol II dynamics using single-molecule assays and reveals how H2A.Z and uH2B modify barrier height and width, affecting transcription.

Using a System’s Equilibrium Behavior to Reduce Its Energy Dissipation in Non-Equilibrium Processes

The paper tests a theoretical framework predicting how to minimize energy dissipation in non-equilibrium processes by controlling the speed of a reaction coordinate based on a generalized friction coefficient.

ATP-dependent force generation and membrane scission by ESCRT-III and Vps4

ESCRT-III and Vps4 were reconstituted to generate ATP-dependent forces for membrane scission, confirming their role in membrane cutting.

Gut microbiome transition across a lifestyle gradient in Himalaya

The paper examines gut microbiome differences across four Himalayan populations with varying lifestyles, finding that microbiome composition is significantly associated with lifestyle changes rather than genetics or geography.

Mechanochemical Coupling and Bi-Phasic Force-Velocity Dependence in the Ultra-Fast Ring ATPase SpoIIIE

This study uses optical tweezers to analyze the mechanochemistry of SpoIIIE, revealing phosphate release as the force-generating step and a bi-phasic force-velocity relationship.