OPA1 protects intervertebral disc and knee joint health in aged mice by maintaining the structure and metabolic functions of mitochondria
V. Madhu, M. Hernandez-Meadows, A. Coleman, K. Sao, K. Inguito, O. Haslam, P. K. Boneski, H. Sesaki, J. A. Collins, M. V. Risbud
This study shows that OPA1 maintains mitochondrial structure and metabolic functions in NP cells and chondrocytes, preventing age-related degeneration in mouse intervertebral discs and knee joints.
bioRxiv · Jan 17, 2024 · PreprintCell Biology