Author

V. Madhu

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:differential expression· 3 Assay:bulk RNA-seq· 2 Assay:ATAC-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

M. V. Risbud· 3 shared A. C. Lepore· 1 shared A. Coleman· 1 shared A. Manchel· 1 shared A. S. Dighe· 1 shared D. H. Nguyen· 1 shared E. J. Novais· 1 shared E. S. Silagi· 1 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersCell Biology

M. V. Risbud

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Author profile →

4 papers

Recent·Most cited

Neuroimmune changes underscore pain-associated behaviors and disc herniations in SM/J mice

E. J. Novais, O. K. Ottone, E. V. Brown, V. Madhu, V. A. Tran, A. S. Dighe, M. D. Solga, A. Manchel, A. C. Lepore, M. V. Risbud

This study identifies SM/J mice as a model for spontaneous disc herniations and shows neuroimmune changes drive chronic discogenic pain.

bioRxiv · Feb 23, 2024 · PreprintCell Biology

OPA1 protects intervertebral disc and knee joint health in aged mice by maintaining the structure and metabolic functions of mitochondria

V. Madhu, M. Hernandez-Meadows, A. Coleman, K. Sao, K. Inguito, O. Haslam, P. K. Boneski, H. Sesaki, J. A. Collins, M. V. Risbud

This study shows that OPA1 maintains mitochondrial structure and metabolic functions in NP cells and chondrocytes, preventing age-related degeneration in mouse intervertebral discs and knee joints.

bioRxiv · Jan 17, 2024 · PreprintCell Biology

GLUT1 is redundant in hypoxic and glycolytic nucleus pulposus cells of the intervertebral disc

S. N. Johnston, E. S. Silagi, V. Madhu, D. H. Nguyen, I. M. Shapiro, M. V. Risbud

The paper shows GLUT1 is functionally redundant in NP cells, as its loss is compensated by GLUT3 and does not affect disc development or viability.

bioRxiv · Jul 22, 2022Cell Biology

Abcc6 null mice a model for mineralization disorder PXE show vertebral osteopenia without enhanced intervertebral disc calcification with aging

P. Boneski, V. Madhu, R. Tomlinson, K. Van de Wetering, I. Shapiro, M. Risbud

This study investigates ABCC6 loss-of-function in mice, showing reduced vertebral bone quality and mild disc degeneration without disc calcification, and suggests potassium citrate as a potential treatment.

bioRxiv · Nov 17, 2021Cell Biology