Author

K. J. Gregory

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:cryo-EM· 1 Approach:mechanistic / dynamical model· 1 Assay:proteomics· 1

Frequent Co-Authors

A. Christopoulos· 1 shared A. Glukhova· 1 shared A. Muraleetharan· 1 shared A. N. Keller· 1 shared C. A. Reynolds· 1 shared D. M. Wootten· 1 shared G. Deganutti· 1 shared H. Venugopal· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperBiochemistry

A. Christopoulos

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2 papers

Recent·Most cited

SCA44- and SCAR13-associated GRM1 mutations affect metabotropic glutamate receptor 1 function through distinct mechanisms

Y. Wang, A. Muraleetharan, K. J. Gregory, S. D. Hellyer

This study investigates how specific mGlu1 mutations affect receptor function in SCA subtypes, revealing distinct mechanisms and potential therapeutic strategies using allosteric modulators.

bioRxiv · Jul 5, 2023 · PreprintPharmacology & Toxicology

Dynamics of GLP-1R peptide agonist engagement are correlated with kinetics of G protein activation

G. Deganutti, Y.-L. Liang, X. Zhang, M. Khoshouei, L. Clydesdale, M. J. Belousoff, H. Venugopal, T. T. Truong, A. Glukhova, A. N. Keller, K. J. Gregory, K. Leach, A. Christopoulos, R. Danev, C. A. Reynolds, , D. M. Wootten

The paper investigates how different GLP-1R agonists affect G protein activation kinetics through structural and functional analyses.

bioRxiv · Mar 10, 2021Biochemistry