Author

Y.-L. Liang

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Pharmacology & Toxicology· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Assay:cryo-EM· 4 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Approach:mechanistic / dynamical model· 1 Research Focus:protein structure prediction· 1 Assay:structural biology· 1

Frequent Co-Authors

R. Danev· 5 shared D. Wootten· 4 shared M. J. Belousoff· 4 shared P. M. Sexton· 4 shared X. Zhang· 4 shared A. Christopoulos· 3 shared A. Glukhova· 3 shared H. Venugopal· 2 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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5 shared papersPharmacology & Toxicology

R. Danev

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5 papers

Recent·Most cited

Pharmacological hallmarks of allostery at the M4 muscarinic receptor elucidated through structure and dynamics

Z. Vuckovic, J. Wang, V. Pham, J. I. Mobbs, M. J. Belousoff, A. Bhattarai, W. A. C. Burger, G. Thompson, M. Yeasmin, K. Leach, E. T. van der Westhuizen, E. Khajehali, Y.-L. Liang, A. Glukhova, D. Wootten, , D. M. Thal

The paper presents cryo-EM structures of the M4 mAChR with ligands and modulators, revealing structural and dynamic insights into allosteric modulation and receptor activation mechanisms.

bioRxiv · Sep 27, 2022Pharmacology & Toxicology

Dynamics of GLP-1R peptide agonist engagement are correlated with kinetics of G protein activation

G. Deganutti, Y.-L. Liang, X. Zhang, M. Khoshouei, L. Clydesdale, M. J. Belousoff, H. Venugopal, T. T. Truong, A. Glukhova, A. N. Keller, K. J. Gregory, K. Leach, A. Christopoulos, R. Danev, C. A. Reynolds, , D. M. Wootten

The paper investigates how different GLP-1R agonists affect G protein activation kinetics through structural and functional analyses.

bioRxiv · Mar 10, 2021Biochemistry

Structure and dynamics of semaglutide and taspoglutide bound GLP-1R-Gs complexes

X. Zhang, M. J. Belousoff, Y.-L. Liang, R. Danev, P. M. Sexton, D. Wootten

This study determines cryo-EM structures of GLP-1R-Gs complexes bound with semaglutide and taspoglutide, revealing similar peptide binding modes but distinct 3D motions compared to GLP-1.

bioRxiv · Jan 12, 2021Biochemistry

Routine sub-2.5 A cryo-EM structure determination of B-family G protein-coupled receptors

R. Danev, M. Belousoff, Y.-L. Liang, X. Zhang, D. Wootten, P. M. Sexton

This study systematically optimizes cryo-EM parameters to routinely determine class B1 GPCR structures at better than 2.5 Å resolution.

bioRxiv · Aug 21, 2020Biophysics

Differential GLP-1R binding and activation by peptide and non-peptide agonists

X. Zhang, M. J. Belousoff, P. Zhao, A. J. Kooistra, T. T. Truong, S. Y. Ang, C. R. Underwood, T. Egebjerg, P. Senel, G. D. Stewart, Y.-L. Liang, A. Glukhova, H. Venugopal, A. Christopoulos, S. G. Furness, , D. Wootten

The paper compares the binding and activation of the GLP-1 receptor by peptide and non-peptide agonists, revealing structural and functional differences that inform drug design.

bioRxiv · Aug 16, 2020Pharmacology & Toxicology