C. A. Reynolds

Dynamics of GLP-1R peptide agonist engagement are correlated with kinetics of G protein activation

The paper investigates how different GLP-1R agonists affect G protein activation kinetics through structural and functional analyses.

Partial agonism improves the anti-hyperglycaemic efficacy of an oxyntomodulin-derived GLP-1R/GCGR co-agonist

This study shows that partial agonism of GLP-1R/GCGR co-agonists improves anti-hyperglycaemic efficacy by reducing β-arrestin-2 recruitment, leading to prolonged glucose-lowering effects and comparable weight loss to liraglutide.

Deciphering the Agonist Binding Mechanism to the Adenosine A1 Receptor

The paper uses molecular dynamics simulations and mutagenesis to study agonist binding to the A1 receptor, identifying new residues and binding modes of CPA-related ligands.

A Multisite Model of Allosterism for the Adenosine A1 Receptor

The paper models allosteric behavior of the adenosine A1 receptor using simulations of PAMs and agonists to explain their functional selectivity and binding properties.

Selective activation of Gαob by an adenosine A1 receptor agonist elicits analgesia without cardiorespiratory depression

The paper identifies BnOCPA as an A1R agonist that selectively activates Gαob, providing analgesia without cardiorespiratory depression.

Extensive memory testing improves prediction of progression to MCI in late middle age

The paper shows that combining multiple memory tests in middle-aged adults better predicts progression to MCI than single tests or biomarkers.