S-acylation targets ORAI1 channels to lipid rafts for efficient Ca2+ signaling by T cell receptors at the immune synapse
A. Carreras-Sureda, L. Abrami, K. JI-Hee, M. Frieden, M. Didier, F. G. van der Goot, N. Demaurex
This study shows that S-acylation of ORAI1 channels at Cys143 by ZDHHC20 is essential for TCR signaling and Ca2+ flux at the immune synapse.
bioRxiv · Feb 3, 2021Biochemistry