F. G. van der Goot

This study shows SARS-CoV-2 infection alters zddhc20 transcription, producing a longer ZDHHC20 protein that enhances Spike acylation and viral infectivity.

This study identifies TMED2 and TMED10 as essential for anthrax toxin oligomerization by controlling lipid nanodomain formation at ER-Golgi contact sites.

The paper identifies a minimal code in the Go subunit N-terminus that governs its localization to the plasma membrane and Golgi, independent of transport, and introduces an assay to study PAT substrate specificity.

The paper shows that S-acylation by ZDHHC20 modifies SARS-CoV-2 membrane proteins, promoting lipid domain formation and enhancing viral infectivity.

This study shows that S-acylation of ORAI1 channels at Cys143 by ZDHHC20 is essential for TCR signaling and Ca2+ flux at the immune synapse.

The paper investigates the molecular mechanism of APT2, showing it interacts with membranes via a hydrophobic loop and S-acylation, deforms lipid bilayers to extract acyl chains, and is subject to ubiquitination and degradation.

The paper identifies ZDHHC2, 8, 15, and 20 as enzymes acylating HA in Influenza A viruses but not Influenza B or C.

The paper identifies DHHC16 as an upstream palmitoyltransferase regulating DHHC6, revealing a palmitoylation cascade and showing dynamic interconversion of DHHC6 species.