L. Abrami

The human-restricted oncoprotein POU5F1B enhances cell invasiveness through plasma membrane remodeling

This study identifies POU5F1B as a human-specific oncoprotein that enhances cell invasiveness via plasma membrane remodeling through ubiquitination and S-acylation.

SARS-CoV-2 shifts transcription of host gene to increase Spike acylation and boost infectivity

This study shows SARS-CoV-2 infection alters zddhc20 transcription, producing a longer ZDHHC20 protein that enhances Spike acylation and viral infectivity.

Anthrax intoxication reveals that ER-Golgi membrane contact sites control the formation of plasma membrane lipid nanodomains

This study identifies TMED2 and TMED10 as essential for anthrax toxin oligomerization by controlling lipid nanodomain formation at ER-Golgi contact sites.

S-acylation controls SARS-Cov-2 membrane lipid organization and enhances infectivity

The paper shows that S-acylation by ZDHHC20 modifies SARS-CoV-2 membrane proteins, promoting lipid domain formation and enhancing viral infectivity.

S-acylation targets ORAI1 channels to lipid rafts for efficient Ca2+ signaling by T cell receptors at the immune synapse

This study shows that S-acylation of ORAI1 channels at Cys143 by ZDHHC20 is essential for TCR signaling and Ca2+ flux at the immune synapse.

Local and substrate-specific S-palmitoylation determines subcellular localization of Gαo

The paper identifies a minimal code in the Go subunit N-terminus that governs its localization to the plasma membrane and Golgi, independent of transport, and introduces an assay to study PAT substrate specificity.

Molecular mode of action of an Acyl Protein thioesterase

The paper investigates the molecular mechanism of APT2, showing it interacts with membranes via a hydrophobic loop and S-acylation, deforms lipid bilayers to extract acyl chains, and is subject to ubiquitination and degradation.

Hemagglutinin of Influenza A, but not of Influenza B and C viruses is acylated by ZDHHC2, 8, 15 and 20

The paper identifies ZDHHC2, 8, 15, and 20 as enzymes acylating HA in Influenza A viruses but not Influenza B or C.

The architecture of the endoplasmic reticulum is regulated by the reversible lipid modification of the shaping protein CLIMP-63

This paper shows that ZDHHC6-mediated S-palmitoylation of CLIMP-63 regulates ER morphology by controlling its localization and abundance in mammalian cells.

Identification and dynamics of the DHHC16-DHHC6 palmitoylation cascade

The paper identifies DHHC16 as an upstream palmitoyltransferase regulating DHHC6, revealing a palmitoylation cascade and showing dynamic interconversion of DHHC6 species.