CD40 provides immune privilege to the bone marrow hematopoietic niche
B. Bassani, A. Gulino, P. Portararo, L. Botti, B. Cappetti, C. Chiodoni, N. Bolli, M. Ciciarello, K. Joehrens, I. Anagnostopoulos, I.-K. Na, A. Curti, C. Tripodo, M. P. Colombo, S. Sangaletti
This study shows that CD40 on bone marrow mesenchymal stem cells (BM-MSCs) promotes immune tolerance and prevents graft-versus-host disease by regulating Treg function and B-cell development.
bioRxiv · Aug 10, 2020 · PreprintImmunology