Author

L. Botti

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:mouse· 6 Research Focus:cell type annotation· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2

Frequent Co-Authors

C. Tripodo· 5 shared M. P. Colombo· 5 shared P. Portararo· 5 shared S. Sangaletti· 5 shared A. Gulino· 4 shared B. Bassani· 4 shared C. Chiodoni· 4 shared A. Curti· 3 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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5 shared papersImmunology

C. Tripodo

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

ZEB1 shapes AML immunological niches suppressing CD8 T-cell activity while fostering Th17 cell expansion.

B. Bassani, G. Simonetti, V. Cancila, M. Ciciarello, A. Piva, C. Chiodoni, D. Lecis, A. Gulino, E. Fonzi, L. Botti, P. Portararo, M. Costanza, J. Schwaller, A. Tzankov, M. Ponzoni, , S. Sangaletti

This study shows ZEB1 in AML suppresses CD8 T-cells and promotes Th17 cells, contributing to immune suppression and tumor progression.

bioRxiv · Jul 8, 2023Immunology

Utilization of an Artery-on-a-chip to unravel novel regulators and therapeutic targets in vascular diseases

V. Paloschi, J. Pauli, G. Winski, Z. Wu, Z. Li, N. Glukha, N. Hummel, R. Rogowitz, S. Meucci, L. Botti, A. Busch, E. Chernogubova, H. Jin, N. Sachs, H.-H. Eckstein, , L. Maegdefessel

The paper develops an artery-on-a-chip model to study shear stress effects on vascular diseases and identifies novel therapeutic targets.

bioRxiv · Nov 29, 2022 · PreprintCell Biology

Neutrophil extracellular traps arm DC vaccination against NPM-mutant myeloproliferation

C. Tripodo, B. Bassani, E. Jachetti, V. Cancila, C. Chiodoni, P. Portararo, L. Botti, C. Vaenti, M. Perrone, M. Ponzoni, P. Comoli, A. Curti, M. P. Colombo, S. Sangaletti

This study demonstrates that neutrophil extracellular traps (NETs) loaded with mutant NPMc+ can be used as a vaccine to treat NPMc-driven myeloproliferation by inducing CD8+ T cell responses and reducing leukemic expansion.

bioRxiv · May 19, 2021Immunology

CD40 provides immune privilege to the bone marrow hematopoietic niche

B. Bassani, A. Gulino, P. Portararo, L. Botti, B. Cappetti, C. Chiodoni, N. Bolli, M. Ciciarello, K. Joehrens, I. Anagnostopoulos, I.-K. Na, A. Curti, C. Tripodo, M. P. Colombo, S. Sangaletti

This study shows that CD40 on bone marrow mesenchymal stem cells (BM-MSCs) promotes immune tolerance and prevents graft-versus-host disease by regulating Treg function and B-cell development.

bioRxiv · Aug 10, 2020 · PreprintImmunology

SPARC regulation of PMN clearance protects from pristane induced lupus and rheumatoid arthritis

S. Sangaletti, L. Botti, A. Gulino, D. Lecis, B. Bassani, P. Portararo, M. Milani, L. De Cecco, M. Dugo, C. Tripodo, M. P. Colombo

This study shows that SPARC deficiency leads to increased PMN clearance failure, promoting autoimmunity in lupus and arthritis models.

bioRxiv · Aug 10, 2020Immunology

Intra-tumor heterogeneity of Diffuse Large B-cell Lymphoma involves the induction of diversified stroma-tumor interfaces

S. Sangaletti, F. Iannelli, F. Zanardi, V. Cancila, P. Portararo, L. Botti, D. Vacca, C. Chiodoni, A. Di Napoli, C. Valenti, M. C. Vegliante, F. Pisati, A. Gulino, M. Ponzoni, M. P. Colombo, C. Tripodo

This study investigates how stromal adaptations in the tumor microenvironment contribute to intra-tumor heterogeneity in DLBCL, showing their impact on transcriptional programs and MYC expression.

bioRxiv · May 30, 2020Cancer Biology