The ubiquitin-conjugating enzyme UBE2D/eff maintains a youthful proteome and ensures protein quality control during aging
L. C. Hunt, K. Nyamkondiwa, A. Stephan, J. Jiao, K. Kavdia, V. Pagala, J. Peng, F. Demontis
This study identifies UBE2D/eff as critical for maintaining proteostasis and a youthful proteome during aging by regulating protein degradation and preventing aggregate accumulation.
bioRxiv · Dec 12, 2023 · PreprintCell Biology