Author

K. Khrapko

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 3

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 3 Approach:statistical model· 3 Assay:DNA methylation· 2 Organism:human· 2 Organism:mouse· 2 Assay:whole-genome sequencing· 2 Organism:chicken / avian· 1 Approach:comparative / phylogenetic analysis· 1

Frequent Co-Authors

K. Gunbin· 3 shared K. PopadiniD· 3 shared S. Oreshkov· 2 shared V. Yurov· 2 shared Z. Fleischmann· 2 shared A. A. Mihailova· 1 shared A. Agranovsky· 1 shared A. G. Mikhailova· 1 shared

Activity by Year

2017-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersEvolutionary Biology

K. Gunbin

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Author profile →

3 papers

Recent·Most cited

Direction mutation pressure of SARS-CoV-2 helps to understand the past and predict the future evolution: C>U and G>U biased mutagenesis forces the majority of amino-acid substitutions to be from CG-rich losers to U-rich gainers

A. Voronka, B. Efimenko, S. Oreshkov, M. Franco, Z. Fleischmann, V. Yurov, A. Trufanova, V. Timonina, N. Ree, A. Zalevsky, E. Penfrat, T. Junier, A. Agranovsky, K. Khrapko, K. Gunbin, , K. Popadin

The paper analyzes SARS-CoV-2 mutagenesis, showing C>U and G>U biases drive amino-acid substitutions from CG-rich losers to U-rich gainers, with implications for vaccine design.

bioRxiv · Aug 22, 2022 · PreprintEvolutionary Biology

A>G substitutions on a heavy chain of mitochondrial genome marks an increased level of aerobic metabolism in warm versus cold vertebrates .

A. G. Mikhailova, D. Iliushchenko, V. Shamanskiy, A. A. Mihailova, K. Ushakova, E. Tretiakov, S. Oreshkov, D. Knorre, L. Polishchuk, D. Lawless, A. Kuzmin, S. Denisov, I. Kozenkov, I. Mazunin, W. Kunz, , K. Popadin

The paper examines A>G substitutions in mtDNA across vertebrates, finding higher rates in warm-blooded species, suggesting temperature influences oxidative damage and mutational patterns.

bioRxiv · Jul 25, 2020 · PreprintEvolutionary Biology

Mitochondrial pseudogenes suggest repeated inter-species hybridization in hominid evolution.

K. Popadin, K. Gunbin, L. Peshkin, S. Annis, Z. Fleischmann, G. Kraytsberg, N. Markuzon, R. R. Ackermann, K. Khrapko

The paper identifies mitochondrial pseudogenes in hominids, suggesting repeated inter-species hybridization during human evolution.

bioRxiv · Oct 19, 2017Evolutionary Biology