ImmunologybioRxivPreprint
TLR-induced reorganization of the IgM-BCR complex regulates B-1 cell responses to infections
H. P. Savage, K. Kläsener, F. L. Smith…·N. Baumgarth
This study shows TLR activation in CD5+ B-1 cells reorganizes the IgM-BCR complex, leading to CD5 loss and increased BCR signaling, which is necessary for plasmablast differentiation during infections.
DOI 10.1101/595694