Author

H. P. Savage

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

A. J. Baumler· 1 shared A. J. Bäumler· 1 shared B. C. English· 1 shared B. H. Abuaita· 1 shared B. M. Young· 1 shared D. J. Bays· 1 shared E. J. Bejarano· 1 shared F. L. Smith· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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1 shared paperImmunology

A. J. Baumler

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

5-ASA can functionally replace Clostridia to prevent a post-antibiotic bloom of Candida albicans by maintaining epithelial hypoxia

H. P. Savage, D. J. Bays, M. A. F. Gonzalez, E. J. Bejarano, H. Nguyen, H. L. P. Masson, T. P. Carvalho, R. L. Santos, G. Thompson, A. J. Bäumler

This study shows that 5-ASA can replace Clostridia to prevent Candida albicans overgrowth by restoring epithelial hypoxia after antibiotic treatment.

bioRxiv · Apr 17, 2023 · PreprintMicrobiology

The IRE1α-XBP1 signaling axis promotes glycolytic reprogramming in response to inflammatory stimuli

B. C. English, H. P. Savage, S. P. Mahan, V. E. Diaz-Ochoa, B. M. Young, B. H. Abuaita, G. J. Sule, J. S. Knight, M. X. O'Riordan, A. J. Baumler, R. M. Tsolis

This study shows that the IRE1α-XBP1 signaling axis enhances glycolysis in macrophages during inflammation, but pathway activation alone is not sufficient to increase glycolytic rates.

bioRxiv · Oct 19, 2022Immunology

TLR-induced reorganization of the IgM-BCR complex regulates B-1 cell responses to infections

H. P. Savage, K. Kläsener, F. L. Smith, M. Reth, N. Baumgarth

This study shows TLR activation in CD5+ B-1 cells reorganizes the IgM-BCR complex, leading to CD5 loss and increased BCR signaling, which is necessary for plasmablast differentiation during infections.

bioRxiv · Apr 2, 2019 · PreprintImmunology