K. Kostarelos

Engineering the glioblastoma microenvironment using TLR7/8 agonist-complexed graphene oxide nanosheets

This paper demonstrates that graphene oxide nanosheets loaded with a TLR7/8 agonist can reprogram tumor-associated macrophages in GBM to a pro-inflammatory state, reducing tumor burden.

Engineering of a graphene oxide-based two-dimensional platform for immune activation and modulation

This study designs graphene oxide-based nanosheets to form stable complexes with the TLR7/8 agonist R848, preserving its biological activity and demonstrating effective macrophage activation.

Functioning human lung organoids model pulmonary tissue response from carbon nanomaterial exposures

This study uses human lung organoids to model pulmonary responses to carbon nanomaterials, showing MWCNTs cause pro-fibrotic effects while GO does not.

Graphene-based thin film microelectrode technology for in vivo high resolution neural recording and stimulation

This paper introduces a graphene-based thin film microelectrode technology for high-resolution in vivo neural recording and stimulation, showing low impedance, high charge injection, and good biocompatibility.

Dynamic interactions and intracellular fate of label-free GO within mammalian cells: role of lateral sheet size

This study investigates how the lateral size of graphene oxide affects its uptake mechanisms and intracellular fate in mammalian cells over time.

Transient Reprogramming of Neonatal Cardiomyocytes to a Proliferative Dedifferentiated State

This study induces transient reprogramming of neonatal rat cardiomyocytes with OSKM factors, leading to dedifferentiation and increased proliferation but not full pluripotency.

Graphene Oxide as 2D Platform for Complexation and Intracellular Delivery of siRNA

This study evaluates graphene oxide as a 2D platform for siRNA delivery without surface modification, showing efficient internalization but limited gene silencing due to rapid siRNA release.

A Novel Scavenging Tool for Cancer Biomarker Discovery based on the Blood-Circulating Nanoparticle Protein Corona

This paper uses lipid-based nanoparticles to capture and analyze tumor-specific proteins in blood, identifying potential cancer biomarkers through mass spectrometry.