Author

K. Kovalchik

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cell-cell communication· 1 Approach:comparative / phylogenetic analysis· 1

Frequent Co-Authors

E. Caron· 3 shared I. Sirois· 2 shared P. Kubiniok· 2 shared A. Marcu· 1 shared A. Tran· 1 shared D. Duque· 1 shared D. Fournelle· 1 shared D. Hamelin· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersImmunology

E. Caron

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Integrated Immunopeptidomics and Proteomics Study Reveals Imbalanced Innate and Adaptive Immune Responses to SARS-Cov-2 Infection

R. Chen, K. M. Fulton, A. Tran, D. Duque, K. Kovalchik, E. Caron, S. M. Twine, J. Li

This study integrates immunopeptidomics and proteomics to show SARS-CoV-2 disrupts antigen presentation and alters HLA protein dynamics in Calu-3 cells.

bioRxiv · Aug 23, 2022 · PreprintImmunology

The mutational landscape of SARS-CoV-2 variants diversifies T cell targets in an HLA supertype-dependent manner

D. J. Hamelin, D. Fournelle, J.-C. Grenier, J. Schockaert, K. Kovalchik, P. Kubiniok, F. Mostefai, J. D. Duquette, F. Saab, I. Sirois, M. Smith, S. Pattijn, H. Soudeyns, H. Decaluwe, J. Hussin, E. Caron

This study analyzes SARS-CoV-2 mutations to show how they diversify T cell targets in an HLA supertype-dependent manner, leading to epitope loss in B7 supertype carriers.

bioRxiv · Jun 3, 2021Immunology

Global Analysis of the Mammalian MHC class I Immunopeptidome at the Organism-Wide Scale

P. Kubiniok, A. Marcu, L. Bichmann, L. Kuchenbecker, H. Schuster, D. Hamelin, J. Despault, K. Kovalchik, L. Wessling, O. Kohlbacher, S. Stevanovic, R. Hans-Georg, M. C. Neidert, I. Sirois, E. Caron

The paper analyzes the MHC class I immunopeptidome across human and mouse tissues, identifying tissue-specific and -independent peptide properties and hyperconserved protein sources.

bioRxiv · Sep 28, 2020 · PreprintImmunology