Author

E. Caron

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5 Biophysics· 1 Cancer Biology· 1 Microbiology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 5 Organism:human· 5 Assay:proteomics· 4 Approach:statistical model· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Organism:mouse· 3

Frequent Co-Authors

N. Grandvaux· 4 shared A. Fortin· 3 shared i. Sirois· 3 shared K. Kovalchik· 3 shared E. Mukawera· 2 shared P. Kubiniok· 2 shared A. Bonnefond· 1 shared A. C. Robitaille· 1 shared

Activity by Year

2017-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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4 shared papersImmunology

N. Grandvaux

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Integrated Immunopeptidomics and Proteomics Study Reveals Imbalanced Innate and Adaptive Immune Responses to SARS-Cov-2 Infection

R. Chen, K. M. Fulton, A. Tran, D. Duque, K. Kovalchik, E. Caron, S. M. Twine, J. Li

This study integrates immunopeptidomics and proteomics to show SARS-CoV-2 disrupts antigen presentation and alters HLA protein dynamics in Calu-3 cells.

bioRxiv · Aug 23, 2022 · PreprintImmunology

Induction of senescence renders cancer cells highly immunogenic

I. Marin, O. Boix, A. Garcia-Garijo, i. Sirois, A. Caballe, E. Zarzuela, I. Ruano, C. Stephan-Otto Attolini, N. Prats, J. A. Lopez-Dominguez, M. Kovatcheva, E. Garralda, J. Munoz, E. Caron, M. Abad, , M. Serrano

This study shows that inducing senescence in cancer cells enhances their immunogenicity, leading to stronger anti-tumor immune responses compared to immunogenic cell death.

bioRxiv · Jun 5, 2022 · PreprintCancer Biology

The mutational landscape of SARS-CoV-2 variants diversifies T cell targets in an HLA supertype-dependent manner

D. J. Hamelin, D. Fournelle, J.-C. Grenier, J. Schockaert, K. Kovalchik, P. Kubiniok, F. Mostefai, J. D. Duquette, F. Saab, I. Sirois, M. Smith, S. Pattijn, H. Soudeyns, H. Decaluwe, J. Hussin, E. Caron

This study analyzes SARS-CoV-2 mutations to show how they diversify T cell targets in an HLA supertype-dependent manner, leading to epitope loss in B7 supertype carriers.

bioRxiv · Jun 3, 2021Immunology

A crosstalk between E2F1 and GLP-1 signaling pathways modulates insulin secretion

C. Bourouh, E. Courty, G. Pasquetti, X. Gromada, N. Rabhi, C. Carney, M. Moreno, R. Boutry, L. Rolland, E. Caron, Z. Benfodda, P. Meffre, J. Kerr-Conte, F. Pattou, P. Froguel, , J.-S. Annicotte

This study shows that E2F1 and GLP-1 signaling pathways interact to regulate insulin secretion and glucose homeostasis in beta cells.

bioRxiv · Apr 16, 2021Physiology

Global Analysis of the Mammalian MHC class I Immunopeptidome at the Organism-Wide Scale

P. Kubiniok, A. Marcu, L. Bichmann, L. Kuchenbecker, H. Schuster, D. Hamelin, J. Despault, K. Kovalchik, L. Wessling, O. Kohlbacher, S. Stevanovic, R. Hans-Georg, M. C. Neidert, I. Sirois, E. Caron

The paper analyzes the MHC class I immunopeptidome across human and mouse tissues, identifying tissue-specific and -independent peptide properties and hyperconserved protein sources.

bioRxiv · Sep 28, 2020 · PreprintImmunology

Pinpointing of cysteine oxidation sites in vivo by high-resolution proteomics reveals mechanism of redox-dependent inhibition of STING

N. Zamorano Cuervo, A. Fortin, E. Caron, S. Chartier, N. Grandvaux

This study identifies thousands of reversible Cys oxidation sites in vivo using a bioswitch method and mass spectrometry, revealing redox-dependent inhibition of STING through Cys206 oxidation.

bioRxiv · Mar 25, 2020Immunology

IFNβ and TNFα cooperate to induce a STAT1-independent antiviral and immunoregulatory program via non-canonical STAT2 and IRF9 pathway

M. Mariani, P. Dasmeh, A. Fortin, E. Caron, M. Kalamujic, A. N. Harrison, D. M. Kasumba, S. Cervantes-Ortiz, E. Mukawera, A. W. R. Serohijos, N. Grandvaux

The paper shows that IFNβ and TNFα together induce a STAT1-independent antiviral program via non-canonical STAT2 and IRF9 pathways.

bioRxiv · Nov 7, 2018 · PreprintImmunology

DUSP1 regulates apoptosis and cell migration, but not the JIP1-protected cytokine response, during Respiratory Syncytial Virus and Sendai Virus infection

A. C. Robitaille, E. Caron, N. Zucchini, E. Mukawera, D. Adam, M. K. Mariani, A. Gelinas, A. Fortin, E. Brochiero, N. Grandvaux

This study shows DUSP1 promotes apoptosis and inhibits cell migration during RSV and SeV infection but does not affect JIP1-protected cytokine responses.

bioRxiv · Nov 26, 2017Microbiology

Structural Basis Of STAT2 Recognition By IRF9 Reveals Molecular Insights Into ISGF3 Function

S. Rengachari, S. Groiss, J. Devos, E. Caron, N. Grandvaux, D. Panne

The paper determines the crystal structures of IRF9-IAD and its complex with STAT2-CCD, revealing structural basis for ISGF3 formation and ISG regulation.

bioRxiv · Apr 28, 2017Biophysics