Structural basis for ligand-induced inactivation of protein tyrosine receptor type Z (PTPRZ): Physiological relevance of head-to-toe RPTP dimerization
A. Fujikawa, H. Sugawara, N. Tanga, K. Ishii, K. Kuboyama, S. Uchiyama, R. Suzuki, M. Noda
This study reveals that PTN-induced inactivation of PTPRZ occurs through head-to-toe dimerization of its tandem PTP domains, which is critical for OPC differentiation.
bioRxiv · May 14, 2019Biochemistry