Author

S. Uchiyama

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Microbiology· 3 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:human· 5 Organism:mouse· 4 Research Focus:host-pathogen & immune response· 3 Research Focus:protein folding & dynamics· 3 Research Focus:cell signaling & trafficking· 2 Assay:protein structure· 2 Assay:proteomics· 2

Frequent Co-Authors

V. Nizet· 4 shared T. Maruno· 3 shared A. Yui· 2 shared D. Kuroda· 2 shared G. Sakoulas· 2 shared K. Tsumoto· 2 shared M. Nakakido· 2 shared S. Nagatoishi· 2 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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4 shared papersMicrobiology

V. Nizet

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Unrecognized Potent Activities of Colistin Against Clinically Important mcr+ Enterobacteriaceae Revealed in Synergy with Host Immunity

M. Kumaraswamy, A. Riestra, A. Flores, S. Uchiyama, S. Dahesh, G. Bondsater, V. Nilsson, M. Chang, H. Seo, G. Sakoulas, V. Nizet

This study reveals that colistin has previously unrecognized bactericidal activity against mcr-1+ Gram-negative bacteria in physiologic conditions and synergizes with host immunity.

bioRxiv · Mar 21, 2023Microbiology

Molecular mechanism underlying the increased risk of colorectal cancer metastasis caused by single nucleotide polymorphisms in LI-cadherin gene

A. Yui, D. Kuroda, T. Maruno, M. Nakakido, S. Nagatoishi, S. Uchiyama, K. Tsumoto

This study investigates how SNPs in the LI-cadherin gene affect cancer metastasis by weakening cell-cell adhesion through reduced homodimerization and altered hydrogen bonding.

bioRxiv · Oct 2, 2022 · PreprintBiochemistry

Elucidation of independently modulated genes in Streptococcus pyogenes reveals carbon sources that control its expression of hemolytic toxins

Y. Hirose, S. Poudel, A. V. Sastry, R. Szubin, D. C. Zielinski, H. G. Lim, N. D. Menon, H. Bergsten, S. Uchiyama, T. Hanada, S. Kawabata, B. O. Palsson, V. Nizet

The paper identifies carbon sources that regulate hemolytic toxin expression in Streptococcus pyogenes using transcriptome-wide independent component analysis.

bioRxiv · Aug 4, 2022Microbiology

Conformational switch in the alpha-synuclein C-terminus domain directs its fibril polymorphs

C. Aguirre, Y. Miyanoiri, M. So, H. Tamaki, T. Maruno, J. Doi, N. Wang, K. Yamaguchi, K. Nakajima, Y. Yamamori, H. Inoura, C.-J. Choong, K. Kakuda, T. Ajiki, Y. Kimura, , H. Mochizuki

This study identifies a conformational switch in the alpha-synuclein C-terminus domain that determines fibril polymorphs by altering morphology in response to ionic strength and temperature.

bioRxiv · Feb 10, 2022 · PreprintBiophysics

Repurposed Drugs Block Toxin-Driven Platelet Clearance by the Hepatic Ashwell-Morell Receptor to Clear Staphylococcus aureus Bacteremia

J. Sun, S. Uchiyama, J. Olson, Y. Morodomi, I. Cornax, N. Ando, Y. Kohno, M. M. T. Kyaw, B. Aguilar, N. M. Haste, S. Kanaji, T. Kanaji, W. E. Rose, G. Sakoulas, J. D. Marth, V. Nizet

Science Translational Medicine · Mar 24, 2021Peer-reviewedMicrobiology

Dimerization mechanism and structural features of human LI-cadherin

A. Yui, J. M. M. Caaveiro, D. Kuroda, M. Nakakido, S. Nagatoishi, S. Goda, T. Maruno, S. Uchiyama, K. Tsumoto

This study determines the crystal structure of LI-cadherin EC1-4 homodimer and shows its unique architecture and noncanonical calcium ion-free linker, revealing the mechanism of homodimerization essential for cell adhesion.

bioRxiv · Sep 18, 2020Biochemistry

PHLPP1 Counter-regulates STAT1-mediated Inflammatory Signaling

K. Cohen Katsenelson, J. D. Stender, A. T. Kawashima, G. Lorden, S. Uchiyama, V. Nizet, C. K. Glass, A. C. Newton

This paper identifies PHLPP1 as a phosphatase that dephosphorylates STAT1 to regulate inflammatory signaling in macrophages, with loss of PHLPP1 protecting mice from sepsis.

bioRxiv · May 24, 2019Biochemistry

Structural basis for ligand-induced inactivation of protein tyrosine receptor type Z (PTPRZ): Physiological relevance of head-to-toe RPTP dimerization

A. Fujikawa, H. Sugawara, N. Tanga, K. Ishii, K. Kuboyama, S. Uchiyama, R. Suzuki, M. Noda

This study reveals that PTN-induced inactivation of PTPRZ occurs through head-to-toe dimerization of its tandem PTP domains, which is critical for OPC differentiation.

bioRxiv · May 14, 2019Biochemistry