K. Ishii

Oncolytic adenovirus serotype 35 mediated tumor growth suppression via efficient activation and tumor infiltration of natural killer cells

This study shows that OAd35 suppresses tumor growth by activating and infiltrating NK cells, with type-I IFN signaling being crucial for NK cell infiltration.

Flow zoometry of Drosophila

This paper introduces flow zoometry, a high-throughput screening method for Drosophila, enabling rapid, automated, and high-resolution analysis of whole animals.

Client recognition differences between PDI and ERp46 to guide oxidative folding

The paper compares how PDI and ERp46 recognize client proteins during oxidative folding, showing distinct mechanisms that influence disulfide bond formation and protein quality control.

Roles of C/EBPα, GATA2, TGF-β-signaling, and epigenetic regulation in the expression of basophil-specific protease genes

The paper investigates the transcriptional regulation of basophil-specific protease genes Mcpt8 and Mcpt11, identifying C/EBPα, GATA2, TGF-β signaling, and epigenetic factors as key regulators.

Apolipoprotein-E transforms intracellular Amyloid-β oligomers to a more toxic state

The paper shows ApoE modifies Aβ oligomers to a more toxic form, detectable in live cells, and presents a potential assay for AD drug discovery.

Single Photon smFRET. III. Application to Pulsed Illumination

This paper applies a Bayesian nonparametric framework to analyze single photon, single molecule FRET data under pulsed illumination, addressing uncertainties and noise sources in Holliday junction experiments.

An attenuated vaccinia vaccine encoding the SARS-CoV-2 spike protein elicits broad and durable immune responses, and protects cynomolgus macaques and human ACE2 transgenic mice from SARS-CoV-2 and its variants

This study develops a vaccinia-based vaccine encoding SARS-CoV-2 spike protein that induces broad and durable immunity, protecting against multiple variants in non-human primates and transgenic mice.

Male-killing-associated bacteriophage WO identified from comparisons of Wolbachia endosymbionts of Homona magnanima

The paper identifies a male-killing-associated bacteriophage WO in Wolbachia strains of Homona magnanima and proposes a mechanism for male-killing evolution.

Direct Photon-by-photon Analysis of Time-Resolved Pulsed Excitation Data using Bayesian Nonparametrics

This paper introduces a Bayesian nonparametric method to directly infer the number of chemical species and their lifetimes from photon arrival data without pre-specifying the number of species.

A Continuous Time Representation of smFRET for the Extraction of Rapid Kinetics

This paper develops a continuous-time hidden Markov jump process to learn kinetic rates from smFRET data beyond acquisition rates, validated on simulated and experimental data.

Quantitative comparison of Drosophila behavior annotations by human observers and a machine learning algorithm

This study compares human and machine learning annotations of Drosophila behavior, showing how human choices affect classifier performance and interpretation.

Structural basis for ligand-induced inactivation of protein tyrosine receptor type Z (PTPRZ): Physiological relevance of head-to-toe RPTP dimerization

This study reveals that PTN-induced inactivation of PTPRZ occurs through head-to-toe dimerization of its tandem PTP domains, which is critical for OPC differentiation.

An asexual flower of Silene latifolia and Microbotryum lychnidis-dioicae promoting its sexual-organ development

The paper investigates how infection by Microbotryum lychnidis-dioicae affects sexual-organ development in an asexual mutant of Silene latifolia, finding that stamen suppression is released but gynoecium suppression is not.