On-line reoptimization of mammalian fed-batch culture using a nonlinear model predictive controller
T. Ohkubo, Y. Sakumura, K. Kunida
This study demonstrates the use of a nonlinear model predictive controller (NLMPC) to reoptimize feeding trajectories in mammalian fed-batch cultures, showing improved mAb yield despite process-model mismatch.
bioRxiv · Dec 28, 2022Bioengineering