T. Fujii

Changes in plant physiology during cultivation periods influence the hydrogen isotope ratio of the water-insect relationship

This study shows that seasonal changes in plant physiology affect the hydrogen isotope ratios in maize leaves and insect tissues, influencing the interpretation of water-source estimates in insects.

High-throughput screening for Cushing's disease: therapeutic potential of thiostrepton via cell cycle regulation

This study identifies thiostrepton as a potential therapy for Cushing's disease by inducing cell cycle arrest in PitNETs through mechanisms independent of FOXM1.

Transcriptomic Landscape of Hyperthyroidism in Mice Overexpressing Thyroid Stimulating Hormone

This study analyzes the transcriptome of hyperthyroid mice overexpressing TSH, identifying novel genes and pathways associated with goiter development and thyroid hormone secretion.

Precise immunofluorescence canceling for highly multiplexed imaging capturing specific cell state

The paper introduces PECAbs for high-specificity multiplexed imaging of cell states and combines them with seq-smFISH to classify cells and identify signal activation states in human tissue.

Cancer-associated Fibroblast Spatial Heterogeneity and EMILIN1 Expression in Cancer Stroma Modulate TGF-beta Activity and CD8+ T-Cell Infiltration in Breast Cancer

This study identifies EMILIN1 as a TGF-beta inhibitor expressed in IFN-gamma CAFs that modulates TGF-beta activity and CD8+ T-cell infiltration in breast cancer.

License to cut: Smart RNA guides for conditional control of CRISPR-Cas9

This paper introduces smart RNA guides that conditionally activate CRISPR-Cas9 in response to specific RNA openers, demonstrating flexibility with miRNA and Boolean logic circuits in mammalian cells.

Silicon as a microfluidic material for imaging and incubation of droplets

This paper demonstrates that silicon chambers improve droplet imaging and incubation by enhancing optical, thermal, and mechanical properties compared to PDMS.

Neural coding of temperature with a DNA-based spiking chemical neuron

This paper introduces a DNA-based chemical neuron that mimics cold temperature sensing by biological neurons through spiking chemical activity and mathematical similarity to a cold nociceptive model.

Two complete genomes of male-killing Wolbachia infecting Ostrinia moth species illuminate their evolutionary dynamics and association with hosts

This study sequenced two male-killing Wolbachia genomes from Ostrinia moths, revealing minimal genome evolution and recent introgression, and provided insights into host-symbiont evolutionary dynamics.

Identification of Lagopus muta japonica plant food resources in the Northern Japan Alps using DNA metabarcoding

This study uses DNA metabarcoding to identify plant food resources of Japanese rock ptarmigans in the Northern Japan Alps, finding 43 plant taxa across 21 families, with Ericaceae being the most dominant.

Manganese toxicity disrupts indole acetic acid homeostasis and suppresses CO2 assimilation reaction in rice plants

This study shows that manganese toxicity in rice reduces indole acetic acid levels, impairing stomatal function and CO2 assimilation, leading to growth defects.

Novel Thyroid-Specific Autoantibodies in Patients with Immune-Related Adverse Events Involving the Thyroid Gland

This study identifies novel thyroid-specific autoantibodies in patients with immune-related adverse events involving the thyroid gland using immunoprecipitation and western blot analysis.

Cryo-EM structure of the MgtE Mg2+ channel pore domain in Mg2+-free conditions reveals cytoplasmic pore opening

The paper determines the cryo-EM structure of MgtE in Mg2+-free conditions, revealing cytoplasmic pore opening and kink motions in TM2 and TM5 helices.

Phylogenetic relationships among the clownfish-hosting sea anemones

This study conducts the largest phylogenetic analysis of clownfish-hosting sea anemones to assess their evolutionary relationships and biogeographic origins.

Development of a microfluidic cell culture and monitoring system for intracellular signaling studies

The paper develops a microfluidic system to control extracellular signal molecule concentrations and measures intracellular Ca2+ responses in CHO-K1 cells.

A survey of public attitudes towards third-party reproduction in Japan in 2014

This study surveys public attitudes towards third-party reproduction and disclosure in Japan, finding that gender, age, and infertility experience influence opinions.

Characterization of genomic DNA of lactic acid bacteria for activation of plasmacytoid dendritic cells .

The paper identifies genomic features of lactic acid bacteria that activate plasmacytoid dendritic cells via TLR9-Myd88, showing CpG motifs and low G+C content are key factors.