ncBAF, a chromatin remodeler, enhances PXR-mediated transcriptional activation in the human and mouse liver
K. Kurosawa, M. Nakano, I. Yokoseki, M. Nagaoka, S. Takemoto, Y. Sakai, K. Kobayashi, Y. Kazuki, T. Fukami, M. Nakajima
This study shows that inhibiting BRD9, a component of ncBAF, reduces PXR-mediated transcriptional activation and associated adverse effects in liver cells and mice.
bioRxiv · Feb 3, 2023 · PreprintPharmacology & Toxicology