M. Nakano

Coatomer complex I is required for the transport of SARS-CoV-2 progeny virions from the endoplasmic reticulum-Golgi intermediate compartment

This study identifies COPI as essential for SARS-CoV-2 virion transport from the ERGIC, showing that COPB2 depletion inhibits viral replication.

Structural basis of Ebola virus nucleocapsid assembly and functions

This study determines the structure of the Ebola virus nucleocapsid using cryo-EM and identifies VP24's role in assembly and function.

ncBAF, a chromatin remodeler, enhances PXR-mediated transcriptional activation in the human and mouse liver

This study shows that inhibiting BRD9, a component of ncBAF, reduces PXR-mediated transcriptional activation and associated adverse effects in liver cells and mice.

Human Dectin-1 is O-glycosylated and serves as a ligand for C-type lectin receptor CLEC-2

This study identifies human Dectin-1 as a ligand for CLEC-2, showing its O-glycosylation enables it to function as a physiological ligand for immune regulation.

vRNA-vRNA interactions in influenza A virus HA vRNA packaging

The paper identifies direct RNA-RNA interactions between HA and PB2 vRNAs in influenza A virus that are critical for selective genome packaging and viral replication.

Single-nucleotide substitution determines pollen production in Japanese cedar

This study identifies a single-nucleotide substitution in the TKPR1 gene that determines pollen production in Japanese cedar and suggests its potential application in creating pollen-free plants.

Autotaxin is a Potential Link between Genetic Risk Factors and Pathogenesis of Systematic Lupus Erythematosus in Plasmacytoid Dendritic Cells

The paper investigates autotaxin's role in SLE by analyzing transcriptome and eQTL data, finding elevated autotaxin levels and its association with interferon-related genes in pDCs.

Immune cell multi-omics analysis reveals contribution of oxidative phosphorylation to B cell functions and organ damage of lupus

The paper identifies oxidative phosphorylation (OXPHOS) as a key driver in SLE B cells, linking mitochondrial dysfunction to immune signaling and organ damage.

Structural insight into Marburg virus nucleoprotein-RNA complex formation

This study determines the structure of the Marburg virus NP-RNA complex using cryo-EM, revealing conserved residues critical for nucleocapsid formation and RNA synthesis between MARV and EBOV.

A chromosome-level genome sequence of a model chrysanthemum: evolution and 1 reference for hexaploid cultivated chrysanthemum

The paper presents a chromosome-level genome sequence of a diploid chrysanthemum, identifies recent retrotransposon activity, and demonstrates its utility for positional cloning and breeding.

The Evolutionary History of Small RNAs in the Solanaceae

The paper uses over 255 small RNA datasets to characterize the small RNA landscape across the Solanaceae family, revealing dynamic evolutionary patterns and genus-specific similarities.

Influenza virus ribonucleoprotein complex formation occurs in the nucleolus

This study identifies the nucleolus as the site of vRNP formation and vRNA replication in influenza virus-infected cells.

Intragenic Complementation of Cellulose Synthase-Like D1 alleles in Root Hair Development

This study identifies and analyzes mutations in the CSLD1 gene in Lotus japonicus, showing their effects on root hair development and suggesting a potential role in root nodule symbiosis.

Microtubule-dependent transport of arenavirus matrix protein demonstrated using live-cell imaging microscopy.

The paper uses live-cell imaging to show that arenavirus matrix proteins are transported via microtubules, with LCMV serving as a safe model for studying LASV-related mechanisms.

A spontaneously blinking fluorescent protein for simple single laser super-resolution live cell imaging

The paper introduces a fluorescent protein, SPOON, that spontaneously blinks in response to light and dehydration, enabling simple single-laser super-resolution imaging.