Sequence signatures of two IGHV3-53/3-66 public clonotypes to SARS-CoV-2 receptor binding domain
T. J. C. Tan, M. Yuan, K. Kuzelka, G. C. Padron, J. R. Beal, X. Chen, Y. Wang, J. Rivera-Cardona, X. Zhu, B. M. Stadtmueller, C. B. Brooke, I. A. Wilson, N. C. Wu
The paper identifies two public IGHV3-53/3-66 clonotypes with distinct CDR H3 motifs and shows Y58F mutation enhances binding affinity to SARS-CoV-2 RBD.
bioRxiv · Jan 26, 2021Microbiology