T. J. C. Tan

Functional and antigenic characterization of SARS-CoV-2 spike fusion peptide by deep mutational scanning

This study uses deep mutational scanning to analyze the SARS-CoV-2 spike fusion peptide, identifying mutations affecting viral entry and antibody resistance.

Evidence of antigenic drift in the fusion machinery core of SARS-CoV-2 spike

This study identifies S2 domain mutations in SARS-CoV-2 spike that reduce binding to antibodies, showing antigenic drift in this region and its impact on vaccine efficacy.

An explainable language model for antibody specificity prediction using curated influenza hemagglutinin antibodies

This study curates a dataset of influenza HA antibodies and develops an explainable language model to predict antibody specificity, identifying and validating HA stem antibodies.

Propagation of human respiratory syncytial virus in cells derived from the black flying fox (Pteropus alecto).

This study shows that human respiratory syncytial virus can propagate in black flying fox kidney cells without prior adaptation, suggesting these cells are a useful model for studying RSV infection.

Widespread impact of immunoglobulin V gene allelic polymorphisms on antibody reactivity

This study shows that IGV allelic polymorphisms widely affect antibody reactivity by analyzing antibody-antigen structures and experimental data.

High-throughput identification of prefusion-stabilizing mutations in SARS-CoV-2 spike

The paper identifies mutations that stabilize the prefusion conformation of SARS-CoV-2 spike while improving expression, using a combination of fluorescence-based assays, cell display, and deep mutational scanning.

Probing the biophysical constraints of SARS-CoV-2 spike N-terminal domain using deep mutational scanning

This study quantifies the effects of NTD mutations on S protein expression and identifies mutations that enhance expression without altering antigenicity.

The evolutionary potential of the influenza A virus hemagglutinin is highly constrained by intersegment epistasis

This study shows that intersegment epistasis between hemagglutinin and neuraminidase constrains the evolutionary potential of the influenza A virus hemagglutinin gene.

Prevalence and mechanisms of evolutionary contingency in human influenza H3N2 neuraminidase

The paper identifies deleterious mutations in human influenza H3N2 neuraminidase and reveals epistatic networks shaping its evolution.

Egg-adaptation pathway of human influenza H3N2 virus is contingent on natural evolution

The paper shows that natural mutations in human H3N2 HA influence the egg-adaptation pathway, affecting mutation emergence during vaccine production.

Interactions between influenza A virus nucleoprotein and gene segment UTRs facilitate selective modulation of viral gene expression

This study identifies how influenza A virus nucleoprotein interactions with gene segment UTRs selectively modulate viral gene expression, revealing a new role for NP in gene-segment specific regulation.

Caprin-1 binding to the critical stress granule protein G3BP1 is regulated by pH

This study shows that Caprin-1 binds to G3BP1's NTF2 domain with pH sensitivity, regulating stress granule formation through a SLiM-mediated mechanism.

Sequence signatures of two IGHV3-53/3-66 public clonotypes to SARS-CoV-2 receptor binding domain

The paper identifies two public IGHV3-53/3-66 clonotypes with distinct CDR H3 motifs and shows Y58F mutation enhances binding affinity to SARS-CoV-2 RBD.