The Genomic Stability at the Coding Regions of the Multidrug Transporter Gene ABCB1: Insights into the Development of Alternative Drug Resistance Mechanisms in Human Leukemia Cells
K. G. Chen, G. E. Duran, M. J. Mogul, Y. C. Wang, K. L. Ross, J.-P. Jaffrezou, L. M. Huff, T. Fojo, N. J. Lacayo, B. I. Sikic
This study develops drug-resistant leukemia cell lines to investigate the mechanisms of cyclosporine's effect on multidrug resistance, finding that ABCB1 remains genetically stable and non-P-gp mechanisms contribute to resistance.
bioRxiv · Oct 28, 2019Cancer Biology