Author

K. G. Chen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1

Frequent Co-Authors

B. S. Mallon· 2 shared D. Maric· 2 shared K. Park· 2 shared P. G. Robey· 2 shared B. I. Sikic· 1 shared F. Yang· 1 shared G. E. Duran· 1 shared J.-P. Jaffrezou· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersBiochemistry

B. S. Mallon

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Metabolic Quadrivalency in RSeT Human Embryonic Stem Cells

K. G. Chen, K. Park, D. Maric, K. R. Johnson, P. G. Robey, B. S. Mallon

This study identifies a unique metabolic state in RSeT human embryonic stem cells characterized by quadrivalency, linking it to growth independence from oxygen and resistance to naive reprogramming.

bioRxiv · Feb 21, 2024 · PreprintBiochemistry

Resistance to Naive and Formative Pluripotency Conversion in RSeT Human Embryonic Stem Cells

K. G. Chen, K. J. Johnson, K. Park, D. Maric, F. Yang, W. F. Liu, Y. C. Fann, B. S. Mallon, P. G. Robey

This study characterizes a new pluripotent state in RSeT hESCs, showing resistance to naive and formative conversion and distinct transcriptomic and signaling features.

bioRxiv · Feb 16, 2024 · PreprintCell Biology

The Genomic Stability at the Coding Regions of the Multidrug Transporter Gene ABCB1: Insights into the Development of Alternative Drug Resistance Mechanisms in Human Leukemia Cells

K. G. Chen, G. E. Duran, M. J. Mogul, Y. C. Wang, K. L. Ross, J.-P. Jaffrezou, L. M. Huff, T. Fojo, N. J. Lacayo, B. I. Sikic

This study develops drug-resistant leukemia cell lines to investigate the mechanisms of cyclosporine's effect on multidrug resistance, finding that ABCB1 remains genetically stable and non-P-gp mechanisms contribute to resistance.

bioRxiv · Oct 28, 2019Cancer Biology