Author

L. M. Huff

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Pharmacology & Toxicology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:drug response / drug discovery· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:cell signaling & trafficking· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

M. M. Gottesman· 3 shared R. W. Robey· 3 shared D. Butcher· 2 shared E. F. Edmondson· 2 shared F. Ali-Rahmani· 2 shared S. V. Ambudkar· 2 shared W. J. E. Frye· 2 shared A. C. Warner· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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3 shared papersPharmacology & Toxicology

M. M. Gottesman

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4 papers

Recent·Most cited

The Multidrug Resistance Transporter P-glycoprotein Confers Resistance to Ferroptosis Inducers

W. J. E. Frye, L. M. Huff, J. M. G. Dalmasy, P. Salazar, R. M. Carter, R. T. Gensler, D. Esposito, R. W. Robey, S. V. Ambudkar, M. M. Gottesman

This study shows that P-glycoprotein (P-gp) and ABCG2 confer resistance to ferroptosis inducers, and some inducers inhibit these transporters, suggesting potential drug-drug interactions.

bioRxiv · Feb 23, 2023Pharmacology & Toxicology

The methyltransferases METTL7A and METTL7B confer resistance to thiol-based histone deacetylase inhibitors

R. W. Robey, C. M. Fitzsimmons, W. M. Guiblet, W. J. E. Frye, J. Gonzalez Dalmasy, L. Wang, D. A. Russell, L. M. Huff, A. J. Perciaccante, F. Ali-Rahmani, C. C. Lipsey, H. M. Wade, A. V. Mitchell, S. S. Maligireddy, D. Terrero, , P. J. Batista

This study identifies METTL7A and METTL7B as methyltransferases that confer resistance to thiol-based HDAC inhibitors by modifying the drug's zinc-binding thiol.

bioRxiv · Oct 7, 2022Cancer Biology

Characterization and tissue localization of zebrafish homologs of the human ABCB1 multidrug transporter

R. W. Robey, A. N. Robinson, F. Ali-Rahmani, L. M. Huff, S. Lusvarghi, S. Vahedi, J. M. Hotz, A. C. Warner, D. Butcher, J. Matta, E. F. Edmondson, T. D. Lee, J. S. Roth, O. W. Lee, M. Shen, , M. M. Gottesman

This study characterizes zebrafish homologs of the human ABCB1 gene, showing that abcb4 closely resembles P-gp in function and localization, while abcb5 differs.

bioRxiv · Feb 18, 2021Pharmacology & Toxicology

The Genomic Stability at the Coding Regions of the Multidrug Transporter Gene ABCB1: Insights into the Development of Alternative Drug Resistance Mechanisms in Human Leukemia Cells

K. G. Chen, G. E. Duran, M. J. Mogul, Y. C. Wang, K. L. Ross, J.-P. Jaffrezou, L. M. Huff, T. Fojo, N. J. Lacayo, B. I. Sikic

This study develops drug-resistant leukemia cell lines to investigate the mechanisms of cyclosporine's effect on multidrug resistance, finding that ABCB1 remains genetically stable and non-P-gp mechanisms contribute to resistance.

bioRxiv · Oct 28, 2019Cancer Biology