Author

K. L. Spiller

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

B. Han· 1 shared B. K. Brisson· 1 shared B. Singh· 1 shared C. E. Witherel· 1 shared D. K. Cullen· 1 shared E. M. O'Brien· 1 shared K. L. Wofford· 1 shared K. Sao· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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1 shared paperBioengineering

B. Han

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Gene Expression Changes in Therapeutic Ultrasound-Treated Human Chronic Wound Tissue

O. Ngo, Z. Abedin, R. DiMaria-Ghalili, M. S. Weingarten, M. Neidrauer, P. A. Lewin, K. L. Spiller

This study identifies gene expression changes in human chronic wound tissue treated with therapeutic ultrasound, finding downregulation of inflammatory genes and upregulation of cell-cell signaling pathways.

bioRxiv · Apr 13, 2022 · PreprintBioengineering

Prior Pro-inflammatory Polarization Changes the Macrophage Response to IL-4

E. M. O'Brien, K. L. Spiller

This study shows that prior M1 activation alters the functional and gene expression profile of M2 macrophages compared to those derived directly from unactivated macrophages.

bioRxiv · Apr 6, 2021Immunology

Regulation of extracellular matrix assembly and structure by hybrid M1/M2 macrophages

C. E. Witherel, K. Sao, B. K. Brisson, B. Han, S. W. Volk, R. J. Petrie, L. Han, K. L. Spiller

This study shows hybrid M1/M2 macrophages regulate ECM assembly, with M2 polarization promoting less fibrotic ECM structure.

bioRxiv · Aug 21, 2020Bioengineering

Non-Genetic Reprogramming of Monocytes via Microparticle Phagocytosis for Sustained Modulation of Macrophage Phenotype

K. L. Wofford, B. Singh, D. K. Cullen, K. L. Spiller

This paper describes a method to reprogram monocytes using microparticles to maintain an anti-inflammatory macrophage phenotype without genetic modification.

bioRxiv · Jun 18, 2019Bioengineering