Author

D. K. Cullen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 10 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 10 Research Focus:cell type annotation· 7 Research Focus:development & morphogenesis· 6 Organism:rat· 6 Research Focus:cell signaling & trafficking· 3 Research Focus:clustering· 2 Assay:electrophysiology· 2 Organism:human· 2

Frequent Co-Authors

K. D. Browne· 5 shared F. A. Laimo· 4 shared J. C. Burrell· 4 shared H. I. Chen· 3 shared L. A. Struzyna· 3 shared Z. Ali· 3 shared D. O. Adewole· 2 shared D. P. Brown· 2 shared

Activity by Year

2018-2021 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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5 shared papersBioengineering

K. D. Browne

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Author profile →

11 papers

Recent·Most cited

Dopaminergic axon tracts within a hyaluronic acid hydrogel encasement for implantation to restore the nigrostriatal pathway

W. J. Gordian-Velez, K. D. Browne, J. H. Galarraga, J. E. Duda, R. A. Espana, H. I. Chen, J. A. Burdick, D. K. Cullen

This paper develops a hyaluronic acid hydrogel-based tissue-engineered nigrostriatal pathway to restore dopamine function in Parkinson's disease by improving axon growth and reducing inflammation.

bioRxiv · Jul 3, 2021Bioengineering

Development of Optically-Controlled "Living Electrodes" with Long-Projecting Axon Tracts for a Synaptic Brain-Machine Interface

D. O. Adewole, L. A. Struzyna, J. C. Burrell, J. P. Harris, A. D. Nemes, D. Petrov, R. H. Kraft, H. I. Chen, M. D. Serruya, J. A. Wolf, D. K. Cullen

This paper develops and validates axon-based 'living electrodes' for a synaptic brain-machine interface, demonstrating their fabrication, function, and in vivo integration in rats.

bioRxiv · Nov 6, 2020Bioengineering

Diverse Changes in Microglia Morphology and Axonal Pathology Over One Year after Mild Traumatic Brain Injury in Pigs

M. R. Grovola, N. Paleologos, D. P. Brown, N. Tran, K. Wofford, J. Harris, K. Browne, J. Wolf, D. K. Cullen, J. E. Duda

This study examines microglial morphology and axonal pathology in pigs with mild TBI over one year, finding persistent microglial morphological changes but no astrocyte reactivity or corpus callosum changes.

bioRxiv · Oct 16, 2020Pathology

Tissue Engineered Axon-Based Living Scaffolds Promote Survival of Spinal Cord Motor Neurons Following Peripheral Nerve Repair

J. C. Maggiore, J. C. Burrell, K. D. Browne, K. C. Katiyar, F. A. Laimo, Z. Ali, H. M. Kaplan, J. M. Rosen, D. K. Cullen

This study compares living and non-living scaffolds for nerve repair, finding that tissue-engineered grafts (TENGs) preserve motor neuron health and function as effectively as autografts.

bioRxiv · Sep 22, 2020Bioengineering

Tyrosine-Derived Polycarbonate Nerve Guidance Tubes Elicit Pro-Regenerative Extracellular Matrix Deposition When Used to Bridge Segmental Nerve Defects in Swine

J. C. Burrell, D. Bhatnagar, D. P. Brown, N. S. Murthy, J. Dutton, F. A. Laimo, Z. Ali, J. M. Rosen, H. M. Kaplan, J. Kohn, D. K. Cullen

This study evaluates tyrosine-derived polycarbonate nerve guidance tubes in swine, showing they promote pro-regenerative extracellular matrix deposition and Schwann cell infiltration compared to collagen-based tubes.

bioRxiv · Jan 11, 2020Bioengineering

Pre-Innervated Tissue Engineered Muscle Promotes a Pro-Regenerative Microenvironment Following Volumetric Muscle Loss

S. DAS, K. D. BROWNE, F. A. LAIMO, J. C. MAGGIORE, H. Kaisaier, C. A. Aguilar, Z. S. ALI, F. MOURKIOTI, D. K. CULLEN

This study develops pre-innervated tissue engineered muscle constructs to enhance regeneration after volumetric muscle loss in rats.

bioRxiv · Nov 13, 2019Bioengineering

Non-Genetic Reprogramming of Monocytes via Microparticle Phagocytosis for Sustained Modulation of Macrophage Phenotype

K. L. Wofford, B. Singh, D. K. Cullen, K. L. Spiller

This paper describes a method to reprogram monocytes using microparticles to maintain an anti-inflammatory macrophage phenotype without genetic modification.

bioRxiv · Jun 18, 2019Bioengineering

Tissue Engineered Axon Tracts Serve as Living Scaffolds to Accelerate Axonal Regeneration and Functional Recovery Following Peripheral Nerve Injury in Rats

K. Katiyar, L. A. Struzyna, J. P. Morand, J. C. Burrell, B. Clements, F. A. Laimo, K. D. Browne, J. Kohn, Z. Ali, H. C. Ledebur, D. H. Smith, D. K. Cullen

This study shows tissue-engineered axon tracts enhance axonal regeneration and functional recovery in rats with sciatic nerve injuries, outperforming nerve guidance tubes and matching autografts.

bioRxiv · May 31, 2019Bioengineering

\"Stretch-Growth\" of Motor Axons in Custom Mechanobioreactors to Generate Long-Projecting Axonal and Axonal-Myocyte Constructs

K. Katiyar, L. Struzyna, S. Das, D. K. Cullen

This paper develops a method to grow long motor axons in vitro using mechanobioreactors and integrates them with myocytes to create axonal-myocyte constructs that mimic native nerve-muscle anatomy.

bioRxiv · Apr 4, 2019Bioengineering

A Computational Model of Bidirectional Axonal Growth in Micro-Tissue Engineered Neuronal Networks (micro-TENNs)

T. Marinov, L. Yuchi, D. O. Adewole, D. K. Cullen, R. H. Kraft

The paper develops a computational model to simulate bidirectional axonal growth in micro-TENNs, capturing 3D axonal tract development and validating it against experimental data.

bioRxiv · Jul 17, 2018Bioengineering

Three-dimensional human axon tracts derived from cerebral organoids

D. K. Cullen, L. A. Struzyna, D. Jgamadze, W. J. Gordian-Velez, J. Lim, K. L. Wofford, K. D. Browne, H. I. Chen

This paper describes the generation of three-dimensional human axon tracts from cerebral organoids, which can be transplanted and mimic brain connectivity features.

bioRxiv · Jan 25, 2018Bioengineering