Author

K. Leiss

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Organism:human· 3 Assay:scRNA-seq· 3 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Approach:biophysical modeling· 1 Approach:deep learning· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

H. Kaessmann· 3 shared I. Sarropoulos· 3 shared K. Okonechnikov· 3 shared L. M. Kutscher· 3 shared M. Sepp· 3 shared P. Joshi· 3 shared S. M. Pfister· 3 shared A. Korshunov· 2 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCancer Biology

H. Kaessmann

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Cell-state plasticity drives heterogeneity in Group 3/4 medulloblastoma

P. Joshi, P. B. G. da Silva, K. Okonechnikov, T. Stelzer, I. Sarropoulos, M. Sepp, J. Nolle, M. V. Pour-Jamnani, A. Rademacher, T. Yamada, C. Schneider, J. Schmidt, L. Bianchini, P. Schaefer, K. Leiss, , L. M. Kutscher

This study identifies cell-state plasticity as a driver of heterogeneity in Group 3/4 medulloblastomas, showing that transcription factor perturbation can redirect tumor cells along different differentiation trajectories.

bioRxiv · Feb 9, 2024 · PreprintCancer Biology

Cellular development and evolution of the mammalian cerebellum

M. Sepp, K. Leiss, I. Sarropoulos, F. Murat, K. Okonechnikov, P. Joshi, E. Leushkin, N. Mbengue, C. Schneider, J. Schmidt, N. Trost, L. Spaenig, P. Giere, P. Khaitovich, S. Lisgo, , H. Kaessmann

This study uses single-nucleus RNA-sequencing to compare cerebellar development across human, mouse, and opossum, revealing conserved and species-specific gene expression patterns.

bioRxiv · Dec 20, 2021Evolutionary Biology

Mapping pediatric brain tumors to their origins in the developing cerebellum

K. Okonechnikov, P. Joshi, M. Sepp, K. Leiss, I. Sarropoulos, F. Murat, M. Sill, P. Beck, K. C.-H. Chan, A. Korshunov, F. Sahm, M. Y. Deng, D. Sturm, J. DeSisto, A. M. Donson, , S. M. Pfister

The paper maps the cellular origins of three common pediatric brain tumors using a single-nucleus atlas and transcriptome data, identifying lineage-specific origins and potential therapeutic targets.

bioRxiv · Dec 19, 2021Cancer Biology