F. Sahm

Characterizing and targeting glioblastoma neuron-tumor networks with retrograde tracing

This study uses retrograde tracing to characterize neuron-tumor networks in glioblastoma and shows that targeting these networks can enhance therapeutic outcomes.

Meningioma transcriptomic landscape demonstrates novel subtypes with regional associated biology and patient outcome.

This study combines bulk RNA-Seq datasets to create a transcriptomic landscape of meningiomas, identifies subtypes with distinct biology and prognosis, and provides an interactive tool for outcome prediction.

Increased mRNA expression of CDKN2A is a transcriptomic marker of clinically aggressive meningiomas

This study investigates the relationship between CDKN2A mRNA expression and clinical outcomes in meningiomas, finding that high expression is associated with poorer progression-free survival and more aggressive tumor characteristics.

The MTORC1-AHR pathway sustains translation and autophagy in tumours under tryptophan stress

This study identifies the MTORC1-AHR pathway as a mechanism sustaining translation and autophagy in tumors under tryptophan stress by enhancing AHR activity and autophagy regulators.

Chromosome 8 gain drives cancer progression by hijacking the translation factor 4E-BP1 sensitizing for targeted CDK4/6 inhibition

This study identifies chr8 gains and 4E-BP1 expression as prognostic markers in Ewing sarcoma, showing they drive cancer progression by promoting proliferation and sensitizing to CDK4/6 inhibitors.

Both YAP1-MAML2 and constitutively active YAP1 drive the formation of tumors that resemble NF2-mutant meningiomas in mice

This study shows that YAP1-MAML2 and active YAP1 drive tumors resembling NF2-mutant meningiomas in mice through TEAD-dependent YAP activity.

Mapping pediatric brain tumors to their origins in the developing cerebellum

The paper maps the cellular origins of three common pediatric brain tumors using a single-nucleus atlas and transcriptome data, identifying lineage-specific origins and potential therapeutic targets.

A connectivity signature for glioblastoma

This paper establishes and validates a connectivity signature in glioblastoma using scRNA-Seq data, showing high connectivity correlates with poor patient survival and specific molecular subtypes.

A subset of pediatric thalamic gliomas share a distinct DNA methylation profile, H3K27me3 loss and frequent alteration of EGFR

This study identifies a distinct subset of pediatric gliomas with EGFR alterations, H3K27me3 loss, and broad tumor localization, suggesting EGFR inhibition as a potential therapy.