Author

J. DeSisto

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 5 Bioengineering· 2

Signature Assays, Organisms & Methods

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Organism:human· 5 Approach:experimental assay· 4 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Research Focus:drug response / drug discovery· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2

Frequent Co-Authors

A. L. Green· 5 shared R. Vibhakar· 4 shared A. Donson· 3 shared A. Green· 2 shared B. A. Orr· 2 shared I. Balakrishnan· 2 shared J. J. Song· 2 shared K.-H. Song· 2 shared

Activity by Year

2019-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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5 shared papersCancer Biology

A. L. Green

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Effect of Microbubble Size, Composition and Multiple Sonication Points on Sterile Inflammatory Response in Focused Ultrasound-Mediated Blood-Brain Barrier Opening

P. J. Martinez, J. J. Song, J. I. Castillo, J. DeSisto, K.-H. Song, A. L. Green, M. A. Borden

This study examines how microbubble size, composition, and sonication points affect blood-brain barrier opening and sterile inflammatory response in mice.

bioRxiv · Apr 28, 2024Bioengineering

Multi-pronged analysis of pediatric low-grade glioma reveals a unique tumor microenvironment associated with BRAF alterations

S. Zahedi, K. A. Riemondy, A. M. Griesinger, A. Donson, R. Fu, M. Crespo, J. DeSisto, M. M. Groat, E. Bratbak, A. Green, T. C. Hankinson, M. Handler, R. Vibhakar, N. Willard, N. K. Foreman, J. M. Mulcahy Levy

This study uses multi-omics approaches to analyze pediatric low-grade glioma and identifies immune-related differences linked to BRAF mutations.

bioRxiv · Apr 5, 2024 · PreprintCancer Biology

Targeting Diffuse Midline Glioma with a novel anti-CD99 Antibody

I. Balakrishnan, K. Madhavan, A. M. Pierce, J. A. Michlin, B. Brunt, S. L. Chetty, D. Wang, J. DeSisto, Z. Nuss, N. Davidson, A. Donson, K. Jones, S. S. Mitra, A. Green, N. Dahl, , S. Venkataraman

This paper identifies CD99 as a therapeutic target in K27M+DMGs, showing that a novel anti-CD99 antibody reduces tumor growth and enhances radiation efficacy in preclinical models.

bioRxiv · Mar 19, 2024 · PreprintCancer Biology

PRMT5 maintains tumor stem cells to promote pediatric high-grade glioma tumorigenesis

J. DeSisto, I. Balakrishnan, A. Knox, G. Link, S. Venkataraman, R. Vibhakar, A. L. Green

This study identifies PRMT5 as essential for pediatric high-grade glioma growth by maintaining tumor stem cells, showing that its inhibition reduces self-renewal and improves survival in preclinical models.

bioRxiv · Mar 12, 2024Cancer Biology

Comprehensive Assessment of Blood-Brain Barrier Opening and Sterile Inflammatory Response: Unraveling the Therapeutic Window

P. J. Martinez, J. J. Song, F. G. Garay, K.-H. Song, T. Mufford, J. Steiner, J. DeSisto, N. Ellens, N. J. Serkova, A. L. Green, M. A. Borden

This study examines how microbubble volume doses and ultrasound mechanical indices affect BBB opening and sterile inflammation in mice, identifying a therapeutic window to optimize safe drug delivery.

bioRxiv · Oct 23, 2023Bioengineering

Mapping pediatric brain tumors to their origins in the developing cerebellum

K. Okonechnikov, P. Joshi, M. Sepp, K. Leiss, I. Sarropoulos, F. Murat, M. Sill, P. Beck, K. C.-H. Chan, A. Korshunov, F. Sahm, M. Y. Deng, D. Sturm, J. DeSisto, A. M. Donson, , S. M. Pfister

The paper maps the cellular origins of three common pediatric brain tumors using a single-nucleus atlas and transcriptome data, identifying lineage-specific origins and potential therapeutic targets.

bioRxiv · Dec 19, 2021Cancer Biology

Comprehensive molecular characterization of pediatric treatment-induced high-grade glioma: A distinct entity despite disparate etiologies with defining molecular characteristics and potential therapeutic targets

J. DeSisto, J. T. Lucas, K. Xu, A. Donson, T. Lin, B. Sanford, Q. T. Tran, D. Hedges, C.-Y. Hsu, G. T. Armstrong, M. Arnold, S. Bhatia, P. Flannery, R. Lemma, L. Hardie, , A. L. Green

This study characterizes treatment-induced high-grade gliomas (TIHGGs) through molecular profiling, identifying distinct subgroups and potential therapeutic targets.

bioRxiv · Oct 29, 2019 · PreprintCancer Biology