Author

A. Rademacher

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:cell type annotation· 3 Approach:deep learning· 3 Assay:scRNA-seq· 3 Research Focus:clustering· 2 Approach:experimental assay· 2 Assay:spatial transcriptomics· 2 Approach:statistical model· 2

Frequent Co-Authors

K. Rippe· 5 shared A. Korshunov· 3 shared B. Statz· 3 shared D. T. W. Jones· 3 shared J.-P. Mallm· 3 shared K. Okonechnikov· 3 shared M. Bortolomeazzi· 3 shared S. M. Pfister· 3 shared

Activity by Year

2017-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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5 shared papersCancer Biology

K. Rippe

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Cell-state plasticity drives heterogeneity in Group 3/4 medulloblastoma

P. Joshi, P. B. G. da Silva, K. Okonechnikov, T. Stelzer, I. Sarropoulos, M. Sepp, J. Nolle, M. V. Pour-Jamnani, A. Rademacher, T. Yamada, C. Schneider, J. Schmidt, L. Bianchini, P. Schaefer, K. Leiss, , L. M. Kutscher

This study identifies cell-state plasticity as a driver of heterogeneity in Group 3/4 medulloblastomas, showing that transcription factor perturbation can redirect tumor cells along different differentiation trajectories.

bioRxiv · Feb 9, 2024 · PreprintCancer Biology

Medulloblastoma oncogene aberrations are not involved in tumor initiation, but essential for disease progression and therapy resistance

K. Okonechnikov, P. Joshi, V. Koerber, A. Rademacher, M. Bortolomeazzi, J.-P. Mallm, P. B. G. da Silva, B. Statz, M. Sepp, I. Sarropoulos, T. Yamada-Saito, J. Vaillant, A. Wittmann, K. Schramm, M. Blattner-Johnson, , S. M. Pfister

The paper uses single-cell technologies to show that large-scale chromosomal aberrations drive medulloblastoma initiation, while single-gene oncogenic events like MYC contribute to progression and therapy resistance.

bioRxiv · Feb 9, 2024Cancer Biology

Compartments in medulloblastoma with extensive nodularity are connected through differentiation along the granular precursor lineage

D. R. Ghasemi, K. Okonechnikov, A. Rademacher, S. Tirier, K. K. Maass, H. Schumacher, J. Sundheimer, B. Statz, A. S. Rifaioglu, K. Bauer, S. Schumacher, M. Bortolomeazzi, F. Giangaspero, K. J. Ernst, J. Saez-Rodriguez, , K. W. Pajtler

The paper uses single-cell transcriptomics to show how two compartments in medulloblastoma are connected through a migrating precursor stage, revealing spatial and developmental links between proliferating and differentiated tumor cells.

Nature Communications · Jan 8, 2024Peer-reviewedCancer Biology

Transcription activation is enhanced by multivalent interactions independent of phase separation

J. Trojanowski, L. Frank, A. Rademacher, P. Grigaitis, K. Rippe

The paper shows that multivalent interactions enhance transcription activation by stabilizing chromatin binding and recruiting co-activators, independent of phase separation.

bioRxiv · Jan 27, 2021Biophysics

Real-Time Observation Of Light-Controlled Transcription In Living Cells

A. Rademacher, F. Erdel, J. Trojanowski, K. Rippe

This study introduces BLInCR, a tool for real-time observation of light-controlled transcription in living cells, showing rapid RNA production and biphasic activation kinetics.

bioRxiv · Apr 28, 2017Cell Biology