Immune potentiator for increased safety and improved protection of vaccines by NF-kB modulation
B. A. Moser, R. C. Steinhardt, Y. Escalante-Buendia, D. A. Bolt, K. M. Barker, S. Yoo, B. G. McGonnigal, A. P. Esser-Kahn
The paper demonstrates a method to reduce vaccine-induced inflammation while enhancing protection by combining an NF-kB inhibitor with adjuvants, showing effectiveness in an influenza model.
bioRxiv · Dec 10, 2018 · PreprintImmunology