Author

A. P. Esser-Kahn

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:drug response / drug discovery· 3 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Research Focus:cell signaling & trafficking· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Q. Chen· 3 shared A. Solanki· 2 shared J. Ajit· 2 shared J. Shen· 2 shared M. G. Rosenberger· 2 shared A. Bahmani· 1 shared A. L. Ferguson· 1 shared B. A. Moser· 1 shared

Activity by Year

2017-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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3 shared papersImmunology

Q. Chen

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5 papers

Recent·Most cited

β-glucan induced trained immunity enhances antibody levels in a vaccination model in mice

J. Ajit, Q. Chen, T. Ung, M. G. Rosenberger, J. Kim, A. Solanki, J. Shen, A. P. Esser-Kahn

This study shows that β-glucan-induced trained immunity in mice enhances antibody levels after vaccination by improving antigen presentation and T-cell responses.

bioRxiv · Apr 11, 2024Immunology

Novel non-immunogenic trained immunity inducing small molecule with improved anti-tumor properties

J. Ajit, H. R. Knight, Q. Chen, A. Solanki, J. Shen, A. P. Esser-Kahn

The paper identifies a small molecule, A1155463, that induces trained immunity in macrophages without being immunogenic, enhancing anti-tumor resistance in mice.

bioRxiv · Mar 22, 2024 · PreprintImmunology

Data-driven discovery of innate immunomodulators via machine learning-guided high throughput screening

Y. Tang, J. Y. Kim, C. K. IP, A. Bahmani, Q. Chen, M. G. Rosenberger, A. P. Esser-Kahn, A. L. Ferguson

This study uses machine learning to guide high-throughput screening and discovers small molecules that modulate innate immune pathways, with some showing up to 15-fold suppression of NF-κB activity.

bioRxiv · Jun 26, 2023Immunology

Immune potentiator for increased safety and improved protection of vaccines by NF-kB modulation

B. A. Moser, R. C. Steinhardt, Y. Escalante-Buendia, D. A. Bolt, K. M. Barker, S. Yoo, B. G. McGonnigal, A. P. Esser-Kahn

The paper demonstrates a method to reduce vaccine-induced inflammation while enhancing protection by combining an NF-kB inhibitor with adjuvants, showing effectiveness in an influenza model.

bioRxiv · Dec 10, 2018 · PreprintImmunology

Light Guided In-vivo Activation of Innate Immune Cells with Photocaged TLR 2/6 Agonist

K. A. Ryu, B. McGonnigal, T. Moore, R. J. Mancini, A. P. Esser-Kahn

This paper introduces a light-based method to activate dendritic cells in vivo, showing time-dependent RNA profile changes in draining lymph nodes.

bioRxiv · Apr 20, 2017Immunology