Targeting CXCR1 and CXCR2 to overcome radiotherapy resistance in PTEN-deficient prostate carcinoma
C. W. D. Armstrong, J. A. Coulter, C. W. Ong, P. J. Maxwell, S. Walker, K. T. Butterworth, O. Lyubomska, S. Berlingeri, R. Gallagher, J. M. O'Sullivan, S. Jain, I. G. Mills, K. M. Prise, R. G. Bristow, M. J. LaBonte, D. J. J. Waugh
This study identifies PTEN-deficiency-associated CXC-chemokine signaling as a driver of radiotherapy resistance in prostate cancer and shows that targeting CXCR1/2 improves radiotherapy outcomes.
bioRxiv · Mar 16, 2020 · PreprintCancer Biology