Author

R. G. Bristow

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cancer Biology· 5

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Organism:human· 5 Research Focus:gene regulatory network inference· 4 Approach:statistical model· 4 Research Focus:chromatin & epigenetic regulation· 3 Research Focus:differential expression· 3 Assay:whole-genome sequencing· 3 Assay:bulk RNA-seq· 2 Approach:experimental assay· 2

Frequent Co-Authors

P. C. Boutros· 4 shared K. Kron· 2 shared M. Lupien· 2 shared A. Gusev· 1 shared A. J. Costello· 1 shared A. Murison· 1 shared A. U. Kishan· 1 shared B. J. Pope· 1 shared

Activity by Year

2017-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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4 shared papersCancer Biology

P. C. Boutros

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5 papers

Recent·Most cited

Germline determinants of the prostate tumor genome

K. E. Houlahan, J. Yuan, T. Schwarz, J. Livingstone, N. S. Fox, W. Jaratlerdsiri, J. van Riet, K. Taraszka, N. Kurganovs, H. Zhu, J. Sietsma Penington, C.-H. Jung, T. N. Yamaguchi, J. Jiang, L. E. Heisler, , P. C. Boutros

The paper identifies germline-determined quantitative trait loci (dQTLs) that influence somatic mutational features in prostate cancer, revealing their impact on tumor epigenome, transcriptome, and proteome.

bioRxiv · Nov 16, 2022 · PreprintCancer Biology

Cis-Regulatory Element Hijacking by Structural Variants Overshadows Higher-Order Topological Changes in Primary Prostate Cancer

J. R. Hawley, S. Zhou, C. Arlidge, G. Grillo, K. Kron, R. Hugh-White, T. van der Kwast, M. Fraser, P. C. Boutros, R. G. Bristow, M. Lupien

The paper shows that structural variants causing cis-regulatory element hijacking have a greater impact on gene expression than changes in three-dimensional chromatin topology in primary prostate cancer.

bioRxiv · Jan 5, 2021Cancer Biology

Targeting CXCR1 and CXCR2 to overcome radiotherapy resistance in PTEN-deficient prostate carcinoma

C. W. D. Armstrong, J. A. Coulter, C. W. Ong, P. J. Maxwell, S. Walker, K. T. Butterworth, O. Lyubomska, S. Berlingeri, R. Gallagher, J. M. O'Sullivan, S. Jain, I. G. Mills, K. M. Prise, R. G. Bristow, M. J. LaBonte, D. J. J. Waugh

This study identifies PTEN-deficiency-associated CXC-chemokine signaling as a driver of radiotherapy resistance in prostate cancer and shows that targeting CXCR1/2 improves radiotherapy outcomes.

bioRxiv · Mar 16, 2020 · PreprintCancer Biology

Divergent mutational processes distinguish hypoxic and normoxic tumours

V. Bhandari, C. H. Li, R. G. Bristow, P. C. Boutros, ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Network

This study identifies hypoxia-associated mutational processes and genomic features across 1,188 tumours from 27 cancer types, showing hypoxia increases mutational load and influences driver mutations and evolutionary trajectories.

bioRxiv · Jan 28, 2019Cancer Biology

Candidate cancer driver mutations in super-enhancers and long-range chromatin interaction networks

L. Wadi, L. Uuskula-Reimand, K. Isaev, S. Shuai, V. Huang, M. Liang, D. Thompson, Y. Li, L. Ruan, M. Paczkowska, M. Krassowski, I. Dzneladze, K. Kron, A. Murison, P. Mazrooei, , J. Reimand

The paper identifies 41 frequently mutated regulatory elements in cancer genomes, enriched in non-coding mutations and linked to gene expression control through chromatin interactions.

bioRxiv · Dec 19, 2017Cancer Biology