Author

I. G. Mills

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 8

Signature Assays, Organisms & Methods

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Organism:human· 7 Approach:experimental assay· 6 Research Focus:cancer & tumor microenvironment· 4 Research Focus:differential expression· 4 Approach:statistical model· 4 Research Focus:cell type annotation· 3 Assay:bulk RNA-seq· 2 Research Focus:gene regulatory network inference· 2

Frequent Co-Authors

A. D. Lamb· 4 shared A. Erickson· 2 shared A. Kiviaho· 2 shared A. Urbanucci· 2 shared B. Vojnovic· 2 shared D. J. Lynn· 2 shared F. C. Hamdy· 2 shared F. Claessens· 2 shared

Activity by Year

2017-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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4 shared papersCancer Biology

A. D. Lamb

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Author profile →

8 papers

Recent·Most cited

Immunosuppression in the prostate tumor microenvironment is tied to androgen deprivation therapy-resistant club-like cells

A. Kiviaho, S. K. Eerola, H. M. L. Kallio, M. K. Andersen, X. Spotbeen, A. Giesen, C. T. A. Parker, S. Taavitsainen, O. Hantula, M. Marttinen, I. Hermelo, M. Ismail, E. Midtbust, M. Wess, W. Devlies, , M. Nykter

The paper identifies club-like cells in the prostate tumor microenvironment that contribute to androgen deprivation therapy resistance through immune suppression.

bioRxiv · Mar 25, 2024 · PreprintCancer Biology

Intra-prostatic tumour evolution, steps in metastatic spread and histogenomic associations revealed by integration of multi-region whole genome sequencing with histopathological features

S. R. Rao, C. Verrill, L. Cerundolo, N. K. Alham, Z. Kaya, M. O'Hanlon, A. Hayes, A. Lambert, M. James, I. D. C. Tullis, J. Niederer, S. Lovell, A. Omer, F. Lopez, T. Leslie, , F. C. Hamdy

This study integrates multi-region whole genome sequencing with histopathological data to reconstruct tumour phylogenies and identify molecular steps in prostate cancer progression and metastasis.

bioRxiv · Feb 27, 2023Cancer Biology

Peroxisomal β-oxidation enzyme, DECR2, regulates lipid metabolism and promotes treatment resistance in advanced prostate cancer

C. Y. Mah, A. D. T. Nguyen, T. Niijima, M. Helm, J. Dehairs, F. J. Ryan, N. Ryan, I. G. Mills, J. V. Swinnen, D. J. Lynn, Z. D. Nassar, L. M. Butler

This study identifies DECR2 as a key driver of treatment resistance in advanced prostate cancer by regulating lipid metabolism and cell cycle progression.

bioRxiv · Nov 5, 2022Cancer Biology

Single-cell ATAC and RNA sequencing reveal pre-existing and persistent subpopulations of cells associated with relapse of prostate cancer

S. Taavitsainen, N. Engedal, S. Cao, F. Handle, A. Erickson, S. Prekovic, D. Wetterskog, T. Tolonen, E. M. Vuorinen, A. Kiviaho, R. Nätkin, T. Häkkinen, W. Devlies, S. Henttinen, R. Kaarijärvi, , A. Urbanucci

The paper uses single-cell ATAC and RNA sequencing to identify pre-existing and treatment-persistent stem-like cell subpopulations in prostate cancer models that predict treatment response.

bioRxiv · Feb 9, 2021Cancer Biology

Tumor irradiation combined with vascular-targeted photodynamic therapy enhances anti-tumor effects in preclinical prostate cancer.

H. T. Sjoberg, Y. J. Philippou, A. L. Magnussen, I. D. Tullis, E. Bridges, A. Chatrian, J. Loefebvre, K. H. Tam, E. A. Murphy, J. Rittscher, D. Preise, L. Agemy, T. Yechezkel, S. C. Smart, P. Kinchesh, , R. J. Bryant

This paper investigates combining fractionated radiotherapy with vascular-targeted photodynamic therapy to enhance tumor control in preclinical prostate cancer models.

bioRxiv · Nov 26, 2020 · PreprintCancer Biology

A feedback loop between the androgen receptor and 6-phosphogluoconate dehydrogenase (6PGD) drives prostate cancer growth

J. L. Gillis, J. A. Hinneh, N. K. Ryan, S. Irani, M. Moldovan, R. K. Shrestha, L.-E. Quek, A. J. Hoy, J. Holst, M. M. Centenera, I. G. Mills, D. J. Lynn, L. A. Selth, L. M. Butler

This study identifies a feedback loop between the androgen receptor and 6PGD that drives prostate cancer growth and shows that targeting both improves therapeutic efficacy.

bioRxiv · Sep 2, 2020Cancer Biology

Targeting CXCR1 and CXCR2 to overcome radiotherapy resistance in PTEN-deficient prostate carcinoma

C. W. D. Armstrong, J. A. Coulter, C. W. Ong, P. J. Maxwell, S. Walker, K. T. Butterworth, O. Lyubomska, S. Berlingeri, R. Gallagher, J. M. O'Sullivan, S. Jain, I. G. Mills, K. M. Prise, R. G. Bristow, M. J. LaBonte, D. J. J. Waugh

This study identifies PTEN-deficiency-associated CXC-chemokine signaling as a driver of radiotherapy resistance in prostate cancer and shows that targeting CXCR1/2 improves radiotherapy outcomes.

bioRxiv · Mar 16, 2020 · PreprintCancer Biology

Mining human prostate cancer datasets: The "camcAPP" shiny app

M. J. Dunning, S. L. Vowler, E. Lalonde, H. Ross-Adams, I. G. Mills, A. G. Lynch, A. D. Lamb

The paper introduces a web-based platform called 'camcAPP' to facilitate access and analysis of human prostate cancer genomic datasets from two cohorts.

bioRxiv · Jan 16, 2017Cancer Biology