A new ferrocene derivative blocks KRAS localization and function by oxidative modification at His95.
K. M. Rehl, J. Selvakumar, D. Hoang, K. Arumugam, A. Gorfe, K.-J. Cho
This study shows a ferrocene derivative inhibits K-Ras function by oxidative modification at His95, blocking its membrane binding and signaling in cancer cells.
bioRxiv · Mar 28, 2023 · PreprintCell Biology