PIP2 promotes conformation-specific dimerization of the EphA2 membrane region
K. M. Stefanski, C. M. Russell, J. M. Westerfield, R. Lamichhane, F. N. Barrera
This study shows PIP2 promotes EphA2 TM dimerization specifically in the ligand-independent conformation by alleviating electrostatic repulsion between JM segments.
bioRxiv · Oct 14, 2020Biophysics