Author

J. M. Westerfield

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

F. N. Barrera· 2 shared A. Cameron· 1 shared A. Sahoo· 1 shared B. Grau· 1 shared C. M. Russell· 1 shared D. S. Alves· 1 shared I. Mingarro· 1 shared J. Schuster· 1 shared

Activity by Year

2020-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersBiophysics

F. N. Barrera

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2 papers

Recent·Most cited

Conformational clamping by a membrane ligand activates the EphA2 receptor

J. M. Westerfield, A. Sahoo, D. S. Alves, B. Grau, A. Cameron, M. Maxwell, J. Schuster, P. C. T. Souza, I. Mingarro, M. Buck, F. N. Barrera

The paper identifies a peptide that activates EphA2 by binding to its transmembrane domain, revealing a mechanism where the peptide acts as a molecular clamp to stabilize the active conformation of the receptor.

bioRxiv · Apr 8, 2021Biophysics

PIP2 promotes conformation-specific dimerization of the EphA2 membrane region

K. M. Stefanski, C. M. Russell, J. M. Westerfield, R. Lamichhane, F. N. Barrera

This study shows PIP2 promotes EphA2 TM dimerization specifically in the ligand-independent conformation by alleviating electrostatic repulsion between JM segments.

bioRxiv · Oct 14, 2020Biophysics