Author

R. Lamichhane

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Biophysics· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 3 Organism:human· 3 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

A. J. Vernall· 3 shared J. E. Ussher· 3 shared R. F. Hannaway· 3 shared S. M. de la Harpe· 3 shared J. D. Tyndall· 2 shared M. Schneider· 2 shared A. Rajkarnikar Singh· 1 shared C. M. Russell· 1 shared

Activity by Year

2019-2020 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersImmunology

A. J. Vernall

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Author profile →

5 papers

Recent·Most cited

PIP2 promotes conformation-specific dimerization of the EphA2 membrane region

K. M. Stefanski, C. M. Russell, J. M. Westerfield, R. Lamichhane, F. N. Barrera

This study shows PIP2 promotes EphA2 TM dimerization specifically in the ligand-independent conformation by alleviating electrostatic repulsion between JM segments.

bioRxiv · Oct 14, 2020Biophysics

Single-molecule view of coordination in a multi-functional DNA polymerase

R. Pauszek, R. Lamichhane, A. Rajkarnikar Singh, D. Millar

The paper uses single-molecule FRET microscopy to study how DNA polymerase I coordinates its polymerase and nuclease activities during DNA replication and repair.

bioRxiv · Aug 12, 2020Biophysics

Neutrophils Suppress Mucosal-Associated Invariant T Cells

M. Schneider, R. F. Hannaway, R. Lamichhane, S. M. de la Harpe, J. D. Tyndall, A. J. Vernall, T. Kettle, J. E. Ussher

This study shows neutrophils suppress MAIT cell activation via cell-contact and H2O2, while activated MAIT cells induce neutrophil death through TNF, revealing a bidirectional regulatory feedback loop.

bioRxiv · Aug 28, 2019 · PreprintImmunology

Type I interferons are important co-stimulatory signals during T cell receptor mediated MAIT cell activation

R. Lamichhane, H. Galvin, R. F. Hannaway, S. M. de la Harpe, F. Munro, J. D. Tyndall, A. J. Vernall, J. L. McCall, M. Husain, J. E. Ussher

This study shows that type I interferons enhance TCR-mediated MAIT cell activation by boosting cytokine and granzyme B production.

bioRxiv · Jul 2, 2019Immunology

Transcriptional analysis defines TCR and cytokine-stimulated MAIT cells as rapid polyfunctional effector T cells that can coordinate the immune response

R. Lamichhane, M. Schneider, S. M. de la Harpe, T. W. R. Harrop, R. F. Hannaway, P. Dearden, J. R. Kirman, J. D. A. Tyndall, A. J. Vernall, J. E. Ussher

This study compares the transcriptional and effector responses of human MAIT cells to TCR and cytokine stimulation, revealing distinct functional outcomes.

bioRxiv · Apr 5, 2019 · PreprintImmunology