Phosphatidylinositol Acyl Chains Configure Priming and Activation of the NLRP3 Inflammasome
C. Hamilton, A. Olona, S. Leishman, K. MacDonald-Ramsahai, S. Cockcroft, G. Larrouy-Maumus, P. K. Anand
This study shows that PI acyl chains regulate NLRP3 inflammasome priming and activation in mouse macrophages through effects on TIRAP and NLRP3 phosphorylation.
bioRxiv · Jan 14, 2020Immunology