G. Larrouy-Maumus

ATP burst is the dominant driver of antibiotic lethality in Mycobacterium smegmatis

The paper investigates how aminoglycoside and fluoroquinolone antibiotics induce cell death in M. smegmatis by increasing TCA cycle flux, ATP production, and ROS, with ATP levels being the primary driver of lethality.

Antimicrobial peptide glatiramer acetate targets Pseudomonas aeruginosa lipopolysaccharides to breach membranes without altering lipopolysaccharide modification

This study shows glatiramer acetate binds and neutralizes Pseudomonas aeruginosa lipopolysaccharides and extracellular DNA, enhancing antibiotic efficacy without inducing resistance mechanisms.

Comparative genomics of carbapenemase-producing Morganella spp.

This study characterizes a large collection of carbapenemase-producing Morganella isolates, revealing new species, intrinsic resistance mechanisms, and potential therapeutic options.

A serine-folate metabolic unit controls resistance and tolerance of infection

This study identifies a serine-folate metabolic pathway regulated by immune signals in Drosophila that affects infection resistance and tolerance.

A universal stress protein acts as a metabolic rheostat controlling carbon flux in mycobacteria

This study identifies a universal stress protein in mycobacteria that regulates carbon flux by acting as a metabolic rheostat, demonstrated through 13C-stable isotope tracing and protein interactions.

Lipid mediated inhibition of Niemann-Pick C1 protein is an evolutionary conserved feature of multiple Mycobacterium lineages and non-tubercular mycobacteria.

This study investigates whether lipid extracts from various mycobacterial strains inhibit the NPC1 pathway, finding that inhibition occurs in most strains but not in Mycobacterium canettii.

Breaking antimicrobial resistance by disrupting extracytoplasmic protein folding

This paper shows that disrupting disulfide bond formation in Gram-negative bacteria sensitizes them to antibiotics by impairing resistance proteins.

Colistin resistance in Escherichia coli confers protection of the cytoplasmic but not outer membrane from the polymyxin antibiotic

This study shows that colistin resistance in E. coli protects the cytoplasmic but not outer membrane from colistin, regardless of resistance mechanism.

Colistin kills bacteria by targeting lipopolysaccharide in the cytoplasmic membrane

This study reveals that colistin kills bacteria by targeting lipopolysaccharide in the cytoplasmic membrane, not the outer membrane, and shows that murepavadin can enhance its efficacy.

Bacillus subtilis YngB contributes to wall teichoic acid glucosylation and glycolipid formation during anaerobic growth

This study identifies YngB as a UGPase in B. subtilis that contributes to WTA glucosylation and glycolipid formation under anaerobic conditions.

Modulation of the cAMP levels with a conserved actinobacteria phosphodiesterase enzyme reduces antimicrobial tolerance in mycobacteria

This study identifies a phosphodiesterase enzyme that reduces cAMP levels in mycobacteria, increasing antimicrobial susceptibility and revealing a new target for antimicrobial development.

Phosphatidylinositol Acyl Chains Configure Priming and Activation of the NLRP3 Inflammasome

This study shows that PI acyl chains regulate NLRP3 inflammasome priming and activation in mouse macrophages through effects on TIRAP and NLRP3 phosphorylation.

The antibiotic bedaquiline activates host macrophage innate immune resistance to bacterial infection

The paper shows that bedaquiline reprograms macrophages to enhance bactericidal activity against bacteria through metabolic and lysosomal pathways.

Fast and robust detection of colistin resistance in Escherichia coli using the MALDI Biotyper Sirius mass spectrometry system

This study adapts the MALDIxin test for the MALDI Biotyper Sirius system to rapidly and reliably detect colistin resistance in E. coli clinical isolates.