In-depth sequence-function characterization reveals multiple paths to enhance phenylalanine ammonia-lyase (PAL) activity.
V. D. Trivedi, T. C. Chappell, N. B. Krishna, A. Shetty, G. G. Sigamani, K. Mohan, A. S. Ramesh, P. Kumar R., N. U. Nair
This study identifies sequence-function relationships in PAL through deep mutational scanning and characterizes mechanisms of activity enhancement.
bioRxiv · Jun 6, 2021 · PreprintBioengineering