Author

T. C. Chappell

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:protein folding & dynamics· 3 Organism:bacteria (other)· 2 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Organism:E. coli· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

N. U. Nair· 5 shared K. Mohan· 2 shared V. D. Trivedi· 2 shared A. J. Tierny· 1 shared A. S. Ramesh· 1 shared A. Shetty· 1 shared C. R. Mace· 1 shared C. S. Bennett· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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5 shared papersBioengineering

N. U. Nair

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5 papers

Recent·Most cited

Rapid spectrophotometric detection for optimized production of landomycins and characterization of their therapeutic potential

T. C. Chappell, K. G. Maiello, A. J. Tierny, K. Yanagi, J. A. Lee, K. Lee, C. R. Mace, C. S. Bennett, N. U. Nair

This study improves landomycin production in Streptomyces cyanogenus using spectrophotometric methods and characterizes their antimicrobial and anticancer activities.

bioRxiv · Nov 7, 2023Bioengineering

In-depth sequence-function characterization reveals multiple paths to enhance phenylalanine ammonia-lyase (PAL) activity.

V. D. Trivedi, T. C. Chappell, N. B. Krishna, A. Shetty, G. G. Sigamani, K. Mohan, A. S. Ramesh, P. Kumar R., N. U. Nair

This study identifies sequence-function relationships in PAL through deep mutational scanning and characterizes mechanisms of activity enhancement.

bioRxiv · Jun 6, 2021 · PreprintBioengineering

Engineered lactobacilli display anti-biofilm and growth suppressing activities against Pseudomonas aeruginosa

T. C. Chappell, N. U. Nair

This study engineers lactobacilli to suppress Pseudomonas aeruginosa biofilm formation and viability using a pathogen-derived enzyme.

npj Biofilms and Microbiomes · Oct 30, 2020Peer-reviewedBioengineering

Directed evolution of Anabaena variabilis phenylalanine ammonia-lyase (PAL) identifies mutants with enhanced activities

Z. J. Mays, K. Mohan, V. D. Trivedi, T. C. Chappell, N. U. Nair

This study uses directed evolution to engineer PAL enzymes from Anabaena variabilis, identifying mutations that enhance activity.

bioRxiv · Feb 20, 2020Bioengineering

Quantifying and engineering mucus adhesion of probiotics

Z. J. S. Mays, T. C. Chappell, N. U. Nair

The paper develops an in vitro assay to measure mucus adhesion of probiotics and demonstrates engineering strategies to control mucoadhesive properties.

bioRxiv · Jan 4, 2020Bioengineering