N. U. Nair

Chromosome 7 to the rescue: overcoming chromosome 10 loss in gliomas

The paper investigates the co-occurrence of chromosome 10 loss and chromosome 7 gain in gliomas, finding functional rescue interactions on chromosome 7 that may compensate for chromosome 10 loss.

Rapid spectrophotometric detection for optimized production of landomycins and characterization of their therapeutic potential

This study improves landomycin production in Streptomyces cyanogenus using spectrophotometric methods and characterizes their antimicrobial and anticancer activities.

A silk-based platform to stabilize phenylalanine ammonia-lyase (PAL) for orally administered enzyme replacement therapy

This paper describes a silk-based platform that stabilizes PAL for oral enzyme replacement therapy in PKU patients.

Transcriptomics based prediction of survival and response to therapy in malignant mesothelioma

The paper identifies a 48-gene prognostic signature and synthetic-lethality profiles predictive of survival and therapy response in mesothelioma using transcriptomic and exomic data from 122 patients.

Sex biases in cancer and autoimmune disease incidence are strongly positively correlated with mitochondrial gene expression across human tissues

In-depth sequence-function characterization reveals multiple paths to enhance phenylalanine ammonia-lyase (PAL) activity.

This study identifies sequence-function relationships in PAL through deep mutational scanning and characterizes mechanisms of activity enhancement.

A landscape of synergistic drug combinations in non-small-cell lung cancer

The paper identifies synergistic drug combinations in non-small-cell lung cancer cell lines, finding that synergy often arises from sensitizing resistant models through dual pathway targeting.

Cross-species identification of cancer-resistance associated genes uncovers their relevance to human cancer risk

The paper identifies cancer-resistance associated genes across species and finds their relevance to human cancer risk through conservation analysis and functional studies.

Engineered lactobacilli display anti-biofilm and growth suppressing activities against Pseudomonas aeruginosa

This study engineers lactobacilli to suppress Pseudomonas aeruginosa biofilm formation and viability using a pathogen-derived enzyme.

Characterization of a membrane enzymatic complex for heterologous production of poly-γ-glutamate in E. coli

This paper expresses and characterizes the PGA Synthetase complex in E. coli, showing its membrane localization and activity, and reports higher PGA production compared to Bacillus subtilis.

Synthetic lethality across normal tissues is strongly associated with cancer risk, onset, and tumor suppressor specificity

The paper quantifies synthetic lethality in normal tissues and links it to cancer risk, onset, and tumor suppressor specificity using GTEx transcriptomics data.

A quantitative model for metabolic intervention using gut microbes

The paper develops a kinetic model to evaluate orally delivered living therapeutics, adapting traditional PK-PD models for engineered bacteria in phenylketonuria treatment.

Directed evolution of Anabaena variabilis phenylalanine ammonia-lyase (PAL) identifies mutants with enhanced activities

This study uses directed evolution to engineer PAL enzymes from Anabaena variabilis, identifying mutations that enhance activity.

Whole exome precision oncology targeting synthetic lethal vulnerabilities across the tumor transcriptome

This paper predicts patient response to cancer therapies using computationally derived genetic interactions across multiple tumor transcriptomics datasets.

Quantifying and engineering mucus adhesion of probiotics

The paper develops an in vitro assay to measure mucus adhesion of probiotics and demonstrates engineering strategies to control mucoadhesive properties.

Surpassing thermodynamic, kinetic, and stability barriers to isomerization catalysis for tagatose biosynthesis

This paper improves the catalytic efficiency of LsLAI for tagatose biosynthesis by encapsulating it in a permeabilized bacterium, achieving high conversion and stability.

Genome-wide prediction of synthetic rescue mediators of resistance to targeted and immunotherapy

The paper predicts synthetic rescue mediators of resistance to targeted and immunotherapy using tumor transcriptomics and survival data from 10,000 TCGA patients, validating predictions through experimental screens.